Pathology and laboratory medicine

pathology, laboratory medicine, clinical pathology laboratories, pathology definition, clinical pathology, pathology laboratory, pathology report, human pathology, lab medicine

Archive for July, 2010

Even mild iron deposits might stimulate hepatitis C

Title: Hepatic stellate cells in hepatitis C patients: Relationship with liver
iron deposits and severity of liver disease
Source: Journal of Gastroenterology and Hepatology      Volume: 19 Number: 1
Page: 91 — 98  
DOI: 10.1111/j.1440-1746.2004.03255.x
Publisher: Blackwell Publishing  
Abstract: Abstract Background and Aim:
To determine the relationship between hepatic stellate cell (HSC) populations
and severity of liver disease and liver iron deposits in patients with chronic
hepatitis C virus (HCV). We also studied the relationship between iron cellular
distribution and HSC population and the role of HFE mutations in the
determination of iron deposits. Methods:
Forty-nine chronic HCV patients with varying degrees of liver damage and liver
iron deposits were studied. A liver biopsy was scored for histology activity
index (HAI), fibrosis and iron deposits. The number of HSC in the liver was
evaluated by an immunohistochemical double-staining method to identify glial
fibrillary acid protein (GFAP) and smooth muscle alpha-actin (a-SMA). Results:
The HSC population was significantly higher in HCV patients than in normal
controls and was predominant in zones 1 and 3. Liver iron deposits were
observed in 49% of patients and were mild/moderate in most cases. We found a
significantly higher number of GFAP and a-SMA positive cells in patients with
liver iron deposits compared with those without iron deposits, and a positive
correlation between liver iron scores and number (%) of GFAP and a-SMA positive
cells. We observed a significantly higher number of GFAP and a-SMA positive
cells in moderate/severe hepatitis than in minimal/mild hepatitis, and a
positive correlation between GFAP and a-SMA positive cells and HAI and fibrosis
scores. Conclusions:
Liver iron deposits in chronic HCV are common and are associated with
activation of HSC. Thus, even mild iron deposits might stimulate HSC and
contribute to liver damage.
© 2004 Blackwell Science
Keywords: chronic hepatitis C; glial fibrillary acid protein; hepatic stellate
cells; iron deposits; smooth muscle alpha-actin

© 2004 Blackwell Science  

Who loves ya.
Jesus Was A Vegetarian!
Man Is A Herbivore!

posted by admin in Uncategorized and have No Comments

Bladder perforation treatment

Hello all, well this may sound unusual but I am having intermittent
catheterisations due to a problem in the bladder, and up to day I was not
trying to use the bladder during the procedure. However I thought to use the
bladder a bit at the end just to make sure the bladder got empty, but
suddenly some "clean"urine started flowing at the beginning, but then it
turned to more and more to dark red and was running along with urine and
then I got a bit panicked and removed the catheter. I do not feel any pain
now, however I am fearing it is possible I perforated the bladder!!!

My question is, does this kind of bladder perforations heal by themselves? I
am using catheter size 12 with xylocaine gel.

Thanks in advance!

posted by admin in Uncategorized and have Comments (4)

solapur medical journal July 2004 issue

Solapur Medical Journal is free web journal published by medical
research council, Dr. V.M.Medical College, Solapur (India). This is
published quarterly & contains research articles, review articles &
interesting case reports.
Site adress is
visit & reply. Your discussion is welcome.
Dr. P.A.Gadgil,
Ass. editor, Solapur Medical Journal

posted by admin in Uncategorized and have No Comments

Microscopy Imaging Survey 2004


To make better products for imaging software we need more information about
the users. Therefore, you can help us to improve the usability of software!
For this reason, it would be very helpful if you could fill out the survey:

You can win 10 gift certificates from AMAZON each 50? worth!

Kind Regards

Daniel Mauch

(Usability Engineer)


Laimer Platz 1

D-80689 Munich


Email: i…

Web: (German)

posted by admin in Uncategorized and have No Comments

What is the medical cause of boxing knockouts?

With the subject of the summer olympics, boxing and wrestleing, and
the likd, it recently occurred to me.

In the general sport known of as ‘boxing’, the general idea is that
barring technical knockouts, a person is supposed to be pounded by
another person by various blows until one of the two people are
generally not able to stand.  They must, however, try to do this while
not trying to harm the legs in any way.

Then it occurred to me, what would cause someone to not be able to
stand after repeated blows, that could be as hard each opponent would
wish to administer, but would still have the shocks of the impacts
delivered evenly distributed by the boxing gloves?

Then I came up with these ideas:

1. Small strokes administered to the central or peripheral nervous

2. Disassociation of the synapses of the central or peripheral nervous
system from the repeated impacts resulting in a coordinative amnesia.

3.The paralysis of various points of the nervous system from the
introduction of fluids from inflammation.

4. Shock from internal hemmoraging.

5. Psychological ‘fainting’, something similar to what women were
sometimes fabled to do in the 1800s.

If you remember, in boxing, no harm is supposed to happen to the legs,
and so it would seem that barring number 5, the only way of getting
someone to not be able to stand would be either at least temporary
paralysis or shock, since there are even rest periods between rounds
to at least somewhat remove the possible tiring of the legs.

What are the medical causes of ‘knockouts’ in boxing?

posted by admin in Uncategorized and have Comments (19)

Iron 'deficiency' protects from malaria

 We conclude that iron deficiency was associated with protection from mild
clinical malaria

 J Infect Dis. 2004 Aug 1;190(3):439-447. Epub 2004 Jul 02. Related Articles,

Iron Deficiency and Malaria among Children Living on the Coast of Kenya.

Nyakeriga AM, Troye-Blomberg M, Dorfman JR, Alexander ND, Back R, Kortok M,
Chemtai AK, Marsh K, Williams TN.

Kenya Medical Research Institute/Wellcome Trust Programme, Centre for
Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, and
Faculty of Health Sciences, Moi University, Eldoret, Kenya; Department of
Immunology, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

Both iron deficiency and malaria are common in much of sub-Saharan Africa, and
the interaction between these conditions is complex. To investigate the
association between nutritional iron status, immunoglobulins, and clinical
Plasmodium falciparum malaria, we determined the incidence of malaria in a
cohort of children between the ages of 8 months and 8 years who were living on
the Kenyan coast. Biochemical iron status and malaria-specific immune responses
were determined during 2 cross-sectional surveys. We found that the incidence
of clinical malaria was significantly lower among iron-deficient children
(incidence-rate ratio [IRR], 0.70; 95% confidence interval [CI], 0.51-0.99;
P<.05), that the incidence of malaria was significantly associated with plasma
ferritin concentration (IRR for log ferritin concentration, 1.48; 95% CI,
1.01-2.17; P<.05), and that iron status was strongly associated with a range of
malaria-specific immunoglobulins. We conclude that iron deficiency was
associated with protection from mild clinical malaria in our cohort of children
in coastal Kenya and discuss possible mechanisms for this protection.

PMID: 15243915 [PubMed - as supplied by publisher]


Who loves ya.
Jesus Was A Vegetarian!
Man Is A Herbivore!

posted by admin in Uncategorized and have No Comments

Needle stick. Where to get a needle tested.

A. After the respondents tell me that the testing of needles are not
   effective, could any of you other folks out there pass me on to
   some organization that tests needles?…

B. If you don’t know the answer to my question could you give me the
   name of a person or institution that could answer where needles are

In a reply, a sentence is constructed as though pcr is some kind of agent.……

C.D.E. In a reply regarding no clinician would ever do that? I guess
       I’m wondering how that is so clear?… Or is there some
       universal protocol ?…  How that can be so definitive?…

F.G.H. I’m puzzled as to how someone could make that claim. Is that
       because doctors have some intuitive understanding?… Or is
       that some universal protocol that doctors have been trained to
       follow without fail ?…

I. Is there a god of manufactured and packaged needles that makes sure
   that all needles are free of infectious agents?…

J. Is this god available automatically and always at work or does someone
   have to pray to make sure that things are up to stuff?…

K. What if you had needles where it appears there is something wrong with
   the manufacturing?…

L. What if kids are found playing with needles on a playground ?…

There is a news story about the school and the teacher who let the
bat go because they would have to kill the bat to test for rabies.

posted by admin in Uncategorized and have Comment (1)

Elevated iron indices in patients with diabetes.

Elevated iron indices in patients with diabetes.
Diabet Med. 2004 Jul

Thomas MC, MacIsaac RJ, Tsalamandris C, Jerums G.

Department of Medicine, University of Melbourne, Austin and Repatriation
Medical Center, Heidelberg, Victoria, Australia.

Abstract Aims Excess iron has been implicated in the pathogenesis of diabetes
and its complications. This study documents the assessment of plasma iron
indices and the correlation between transferrin saturation with biochemical and
clinical parameters in a cross-sectional survey of 820 patients with diabetes
in long-term follow-up in a single clinic. Methods Plasma iron indices,
together with the biochemical and clinical profile of all patients, were
recorded over a 2-year period. Predictors of the transferrin saturation were
identified using multiple and logistic regression analysis. Results Eighty per
cent of patients had Type 2 diabetes. The prevalence of elevated transferrin
saturation (> 35%) was 3-4-fold higher in patients with diabetes, compared with
historical prevalence described in the general population. Independent
associations with elevated transferrin saturation were male gender, low
C-reactive protein, and increased fasting plasma glucose (all P < 0.0001).
Patients with Type 1 diabetes were also more likely to have an elevated
transferrin saturation [odds ratio 3.9 (95% CI 1.9-8.0), P < 0.001]. Patients
with an elevated transferrin saturation were younger, but had a similar
duration of diabetes, possibly suggesting an earlier age of onset. There was no
correlation between the presence of diabetic complications and the presence of
elevated iron indices. Conclusions Elevated iron indices are more common in
patients with diabetes. Excess iron may have a role in the development of
diabetes and subsequently in glycaemic control. This should be balanced by the
strong association between iron indices and anaemia in patients with diabetes.
Diabet. Med. 21, 798-802 (2004)

PMID: 15209778 [PubMed - in process]


Who loves ya.
Jesus Was A Vegetarian!
Man Is A Herbivore!

posted by admin in Uncategorized and have No Comments

severe hypercholesterolaemia or coronary artery disease

 LDL apheresis should be available in all health regions

Tidsskr Nor Laegeforen. 2004 Apr 22;124(8):1085-7.  Related Articles, Links  

[Apheresis in severe hypercholesterolaemia]

[Article in Norwegian]

Graesdal A, Hovland A, Bjorbaek E.

Lipidklinikken Nordlandssykehuset, Bodo. a…

BACKGROUND: Hypercholesterolaemia is usually successfully treated with statins
but in some cases the medication has insufficient cholesterol-lowering effect
or is not well tolerated. In these instances LDL apheresis is an option.
MATERIAL AND METHODS: We share some of our own experience with this treatment
and then review the literature regarding LDL apheresis. RESULTS: LDL apheresis
seems a safe and effective way of lowering LDL cholesterol. Mortality and
morbidity is reduced in selected patient groups. Quite probably, too few
Norwegian patients are offered this treatment. INTERPRETATION: LDL apheresis
should be available in all health regions of Norway and the treatment should be
known to all those who treat severe hypercholesterolaemia or coronary artery

PMID: 15114383 [PubMed - indexed for MEDLINE]


Who loves ya.
Jesus Was A Vegetarian!
Man Is A Herbivore!

posted by admin in Uncategorized and have No Comments

Needles. Syringes. Testing for infectious organisms.

Thank you all for your interest !

Would someone actually send along the name of a laboratory or names of laboratories
that would test needles, syringes for infectious organisms, a laboratory where a doctor
could have a needle, syringe tested in a case where the test results make a
difference in treating the patient ?…

Just because an organism is dead does not mean you can not test for dna. That is the
thing about dna that makes it testable days, weeks, years after the fact.  DNA is tough,
resistant to deterioration. DNA is a persistent molecule.

See also

posted by admin in Uncategorized and have Comments (8)