Pathology and laboratory medicine

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Archive for May, 2011

** HELP: Applying Vit E to lip laceration minimizes suture scars?? **

Hello,

FACTS:

I was treated 3 days ago in ER for a lip laceration, through and through,
suffered by someone’s elbow hitting me while playing basketball (!).
(elbow hit my upper incisor(?) tooth – the super sharp one – my
lip happened to be in the middle of this elbow-on-tooth trauma…
We did win the game!)

Outer lip had a V laceration (2 cuts in the shape of a V) each about
about 0.5 cm long – and needing 8 stitches total, non-disolving.

Inner lip/mouth had a 2mm hole – needing 2 stitches – disolving type.

I’m washing the laceration 2x daily with 50/50 water/hydrogen peroxide
and then covering with Neosporin, then covering with a band-aid.

Sutures are set to come out this Monday (about 5 days post suturing).

I plan to use an SPF 15 lip balm (chapstick w/ spf) post-suture removal
for ‘a while’.

QUESTIONS:

1. is 5 days the optimal # of days for sutures for this kind of laceration?
   (optimal meaning: best trade off between wound closure and minimization
    of suture marks and lac. scars)

2. can waiting an extra 2 days for suture removal make a difference in
   the appearance of the scar or suture marks/scars a year down the road or
   longer?

3. is there anything I could be doing to minimize the future appearance
   of a scar from the laceration or scars from the sutures?

4. can applying raw Vitamin E oil to the lacerations now or post-suture
   removal help in minimizing the future appearance of a scar from the
   laceration or scars from the sutures?

5. can applying *anything* to the lacerations now or post-suture
   removal help in minimizing the future appearance of a scar from the
   laceration or scar from the sutures?

Thanks for any help/pointers/recommendations to my questions.

Replies to:

  a…@netcom.com

witchcraft supplies print catalogs .
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Re: Cerner SNOMED autocoder

 G. William Moore, MD, PhD.
 Deputy Chief, Autopsy Section
 Pathology & Lab Medicine Service (113)
 Veterans Affairs Maryland Health Care System
 10 North Greene Street
 Baltimore, MD 21201-1524
 TEL: 1-410-605-7000 ext 5313
 FAX: 1-410-605-7911
 email (work): moore.geo…@baltimore.va.gov
 email (home): gvwmo…@ix.netcom.com

 Re:  The Cerner SNOMED Autocoder discussion.
 I believe that we have solved the ‘no evidence of malignancy’
 problem for the SNOMED-autocoder used by the Internet Autopsy
 Database (IAD) website:
           http://www.med.jhu.edu/pathology/iad.html
 The design for our autocoder, written in the M-language
 (formerly, MUMPS), is described in two files that are
 downloadable from the IAD website, namely, IADBREAD.HTM (readme)
 and IADBFAQQ.HTM (frequently asked questions).  The complete
 M-language source code is listed in file IADBMROU.TXT,
 although this file is rather disorganized, and we do not
 recommend that users spend too much time with it.  A more
 user-friendly version of this source-code is under development.

     If you are encoding with the latest edition of SNOMED,
 i.e., SNOMED III or SNOMED International, there is a set
 of G-codes, which includes all the common modifiers, like NEGATIVE,
 POSITIVE, MILD, MODERATE, MARKED, etc., which are used in
 coding pathologic diagnoses.  I don’t know whether the Cerner
 autocoder manages G-codes, but if it does not, then it
 should.  In order to encode ‘no evidence of malignancy’,
 all you need is to construct a compound SNOMED sentence
 containing NEGATIVE and MALIGNANCY.

     The compound SNOMED sentence points out a much more serious
 issue, which is that there is no official syntax for SNOMED.
 Negatives aren’t the only problem: How to you say,
 ’adenocarcinoma of prostate, metastatic to lung’?
 This sentence contains two SNOMED Topography concepts (prostate,
 lung), one Morphology concept (adenocarcinoma), and a G-concept
 (metastatic-to).  The concept-order makes a lot of difference
 in transmitting the correct meaning (semantics) of the sentence.

     One solution is to use English syntax.  Aside from the offense
 that this policy might give to many international users of SNOMED,
 there really is no unambiguous English syntax.  Which is correct?
               adenocarcinoma of prostate.
               prostate adenocarcinoma.
 If both concept-orders are permissible, then we have a system
 in which there are (at least) two ways to say exactly
 the same thing.  For 3-concept, 4-concept (e.g., the metastasis
 example), etc., sentences, this combinatoric tower of Babel
 grows rapidly.  If we have a language (SNOMED) in which there
 are many ways to say exactly the same thing, then we place an
 enormous potential burden on search algorithms and database
 management in anatomic pathology.

     In the Internet Autopsy Database (IAD), we have attempted nothing
 further than to translate words or concepts in the exact order
 as they appear in the original autopsy facesheet, and to identify
 the end of each sentence or diagnostic phrase.  In this, we have
 been less than entirely successful, but we are incrementally
 improving the autocoder to achieve these goals.  Although we
 have not imposed a preferred syntax on the IAD, we expect to
 do so in the future.

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Looking for blood info

I am looking for a resource on the net that gives minor descriptions
of each of the items in a Chem 25 blood panel and a CBC/hemograhm. A
good book put in lay terms would be good as well.

I am looking for information such as what does albumin do and not do,
what does an elevated or depressed BUN mean, etc. Also current
reference numbers.

I have done all the standerd searches and have come up blank. I know
it is out there , I am just not using the right buzz words.

You can e-mail me as well as post here. Perhaps some one else would
like to know these things as well.

Thank you in advance,

Kendal Jackson
jacks…@ucs.orst.edu
Executive Chef
Oregon State University

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medical lab technician interview for electronic magazine

Hello,
Sorry to barge in on your newsgroup like this…
I’m a journalist with an electronic magazine called "Career Explorer
Online"; a database of career information on Canada and the USA.
Currently, I’m writing an article on medical lab technicians and would
like to talk with people working in this field to find out more about some
of the challenges, rewards and requirements of this career. If you’re a
medical lab technician, or you know of someone in this field who would be
willing to be interviewed, please contact me.
The interview could be conducted via email or by phone, which ever is most
convenient, and I can be contacted at the sources listed below.
Thanks for your time. Looking forward to hearing from you.
Regards,
Carolynn Van de Vyvere
Career Explorer Online
cvand…@awinc.com
604-860-2036 (Pacific Standard Time)

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Migration Inhibitory Factor (MIF)

         It is my understanding that T cells, macrophages, IL4 and IFN gamma
all secret or exert an effect upon MIF.  I was wondering to what degree
these cells or compounds have an effect and which cell or compound, if
any, exhibits the most predominant effect.  Also, is the secretion of
MIF a primary effect of the cells that produce it or is it a result of a
cascade of events?

A timely response is greatly appreciated!!!
Thank-you

Catherine M. Falkner
falkn…@ccmac.canisius.edu

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Why Americans should be worried

Hi everybody!

   This is a very informative article on mad cow disease–something for
us, Americans, to think about…

    Last week, British Health Secretary Stephen Dorrell finally bit the
bullet and announced that bovine spongiform encephalopathy, commonly
known as "mad cow disease" or BSE, can be transmitted to humans.  This
about-face came after a decade of stonewalling by the British
government.

    British officials finally realized they could no longer ignore the
opinions of leading scientists and the increasing number of cases of
Creutzfeldt-Jakob disease (CJD), an affliction similar to BSE, which
humans may contract if they eat cattle with mad cow diease.  British
doctors diagnosed 55 new cases of CJD en 1994–13 more than the year
before and double the rate of a decade ago.

    BSE and CJD are hideous diseases.  They eat away the nervous system,
destroying the brain, essentially turning it into a sponge.  Victims
suffer dementia, confusion, loss of speech, sight and hearing,
convulsions, coma and death.  Spongiform encephalopathies are always
fatal and there is no treatment.

    British beefeaters who have not yet lost their minds are backing off
their steak and kidney pies in droves.  McDonald’s chains in Britain
have announced they will not sell hamburgers until a non-Britishsource
of beef can be found.  More than 2,000 schools have removed beef from
their menus.  France and Belgium have suspended the importation of
British beef and Germany is pushing for a Europe-wide ban.  A panicked
Britain is even considering killing its entire national herd–more than
11 million cattle–and starting over from scratch.

    Trouble is, much of this damage control may be too late, CJD has an
incubation period of 10 to 40 years.  Many falling victim to the disease
today may have contracted it a decade ago when the BSE epidemic began.

    Americans, too, should think twice before throwing burgers on the
grill.  Why?  Because BSE may already be here, even though the U.S. has
not imported beef or cattle from the British since 1989.

    In 1985, 7,000 minks in Stetsonville, Wis., died of transmissible
mink encephalopathy after being fed a consistent diet of so-called
"downer" cows–cattle who collapse on the arduous journey from feedlot
to slaughterhouse.  Scientists believe that some downer cows suffer from
mad cow disease.  It’s hard to tell, because it can take up to eight
years from the time of infection for symptoms to show–and most U.S.
cattle are dead before their fifth birthday.

     These animals are never tested for BSE.  They are ground up and fed
to somebody–humans, dogs, cats, minks and other cattle.

     Since the BSE outbreak in England was traced to protein supplements
that included scrapie-infected sheep–scrapie is the sheep version of
mad cow disease–Britain has banned the use of ruminant parts in animal
feed.  No such ban is in effect here.  Cows and sheer are still being
fed to cows.  BSE could be a sleeping dinosaur.

     Physicians and scientists alaready know that some Americans with
CJD were incorrectly diagnosed with Alzheimer’s, a disease with similar
symptoms.  Did the CJD originate in the cattle served up for supper?

     It is grossly unnatural to feed other animals to cattle, who are
natural vegetarians.  But the demands made upon cows by today’s
"factory" farms aren’t natural either.  Animals crammed into warehouses
and feedlots must be shipped off to slaughter quickly, before the
hellish conditions kill them.  Consequently they are forced to grow ever
bigger, ever faster, through the use of growth hormones, antibiotics and
high-protein feeds.  As Rutgers University biology professor Dr. David
Ehrenfeld recently wrote: "CJD…has not been listed as a side effect of

factory farming…Maybe it should be."
(The Charlotte Observer, 3/26/96)

     Scary, isn’t it?  How can they feed other animals to cattle?!  
What an unconceivable shame and ignorance.  No wonder we are so plagued
with so many diseases of unknown origen.

     Someone who cares,

     Diane

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Conference Announcement, U. Michigan, Ann Arbor, June 5-7

Dear newsgroup readers:

This note will alert you to an upcoming conference, the 14th Annual
"Automated Information Management in the Clinical Laboratory," which may
be of interest to you or your colleagues.  It will be held at the
University of Michigan, Ann Arbor, from June 5-7.  Further details,
including the entire Registration Brochure (in both .HTML and .PDF
formats), are available at http://www-aimcl.path.med.umich.edu or by
calling 800/962-3555 and asking for Postgraduate Medicine.  Please feel
free to forward this message, or to make a link to our URL from your
website.  We apologize for any multiple copies of this posting which you
may receive.  Thanks for any interest, Bruce Friedman and Mike Lougee
(U. Michigan Dept. of Pathology, Course Director and Associate Course
Director, respectively).

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Contact address please

I know it’s a dumb thing to do, and violates netiquette.
Anyway, I’m looking for a contact number for
Dr. Chris Souter at Barts in London.

I have tried the Barts switchboard, and the QMW Web pages,
honest!

TIA
John Hearns

(BTW, anyone else involved in telepathology in the UK
  is welcome to drop me a line).


================================================================
| Dr. John Hearns : Guy’s and St. Thomas’ Hospitals, London    |
| email : j.hea…@umds.ac.uk  Tel: +44 171 922 8072           |
| www   : http://www-ipg.umds.ac.uk/~johnh/                    |

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relapsing polychondritis


BM(0
i am a french doctor and i search for new experiment in treatment of the
relapsing polychondritis. Thank you to send me the tittle of articles
about this subject and, if exist, the web link.

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Approved treatment for MI

NEWS INFORMATION                19 APRIL, 1996

ZESTRIL APPROVED FOR TREATMENT OF ACUTE MI.

The angiotensin-converting enzyme (ACE) inhibitor Zestril (lisinporil) has been approved
in Australia for the treatment of acute myocardial infarction (MI), ICI Pharmaceuticals
announced today.

‘Zestril’ is already registeered in Australia for the treatment of hypertension and
congestive heart failure.

According to the results of a four-country survey of European cardiologists, almost one
half of MI patients, during the acute phase, are already being prescribed an
ACE-inhibitor in addition to standard coronary car.(1)

Early treatment with Zestril, begining with 24 hours of acute MI, in haemodynamically
stable patients has been shown by the GISSI-3 study to significantly reduce the risk of
both mortality and severe left ventricular (LV) dysfunction after six weeks of
treatment. (2)

Furthermore, at six months follow-up there was a significant reduction in the risk of
severe LV dysfunction in those patients who had been randomised to receive Zestril
during the six week treatment phase.

Speaking on behalf of the GISSI group, Professor Gianni Tognoni emphasised the
additional benefit to be gained from the early use of Zestril in acute MI.

"Of the 72 deaths avoided in patients receiving Zestril in the first 42 days after acute
MI, 21 were within the first day and 54 within the first five days," he said.

Commenting on the six months results, Prof. Tognoni said GISSI 3 had not only shown a
treatment benefit with Zestril in acute MI, but also a prevention benefit in terms of a
persistent reduction of severe LV dysfunction after withdrawl of the drug.  "This
important finding further supports the potential of ACE-inhibitors in acute MI," he
said.

        Zestril is distributed by ICI Australia Operations Pty Ltd on behalf of Zeneca  
        Ltd owners of the Zestril Trademark.  Zeneca has been the name of ICI          
        Pharmaceuticals overseas since the beginning of 1993.

For further information reply to the above.

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