Pathology and laboratory medicine

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Archive for April, 2012

re: H. pylori and Crohn's or UC

It is interesting that many UC patients respond  to azulfadine therapy
(given sometimes after a colonoscopy) with at least a brief period of
remission.  Makes you think that there may indeed be a bacterial connection
of some kind.  Another puzzler is why Crohn’s and UC patients experience
reduction of symptoms for a little while after the "big cleanout" that they
have to do before the colonoscopy–even if they return immediately to usual
(and sometimes not ideal) diets right after.  
Do any of you folks have any thoughts on these subjects?

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blood cells in urine

please help!  I can’t find the detailed info I want on the Net.

Does anybody know, or know where I can find, what it means if blood
cells found in the urine do not cling to each other?

Thanks for any input offered.

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Replacement Microscope Lamps.

Technical Lamp Supplies Ltd. are a UK based distributor of OSRAM and USHIO
Mercury Arc Lamps. We can offer lamps used in Leica, Nikon, Olympus,
Reichert and Zeiss Microscopes.
Please email us for a price quotation.

Kind regards
Nick Simmonds.

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sending samples…

Dear Pathologists,

 anybody ever send frozen tumour samples from the USA to Europe?
If yes, I would be grateful for knowing about your experience with
different routes (e.g., way of storage, companies to trust for
handling, …)

 Thank you very much!

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Info to work abroad

Hi, I’m looking for knowing how a brasilian physioterapist (with degree and
work experience in cardiopulmonary reabilitation) can work in Switzerland
or in the USA. I know that in Italy is impossible.
Is there somebody can help me?
Please send me an e-mail to jj…
Thanks in advance
Gianluigi Miotto

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extraction hoods

WIBO Belgium a reputed producer and supplier of extraction units offer you a
complete range of systems for the pathology department. From small boxes to
the most complex tables… and your wishes come true. No smell, no particles
in your breathing zone, a perfect extraction of solvents and still free to

With our WIBOjekt system we’ll offer you a minimal quantity of air
extraction. A guanteed free breathing zone is provided.

Interested ? Send us your co-ordinates at Wibo.Belg…

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Does anybody know where I can go to find out anything about genetics. If you
can please email me at Sandi…  I appreciate your help

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mouse tail vein catheters

Has anybody experiences with mouse tail vein catheters (handling,
material)? I would be glad to get some informationes.

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H.R. 4028. ~ Silicone Breast Implant Research and Information Act

- — -

>  2d Session
>                                H. R. 4028

>  To promote research to identify and evaluate the health effects of
> silicone breast implants, and to ensure that women and their doctors
>           receive accurate information about such implants.



>                             June 10, 1998

>  Mr. Green introduced the following bill; which was referred to the
>                         Committee on Commerce


>                                 A BILL

>  To promote research to identify and evaluate the health effects of
>silicone breast implants, and to ensure that women and their doctors
>receive accurate information about such implants.

>    Be it enacted by the Senate and House of Representatives of the
>United States of America in Congress assembled,


>    This Act may be cited as the “Silicone Breast Implant Research and
>Information Act”.


>    (a) Findings.–Congress makes the following findings:
>    (1) According to the Institute of Medicine, it is estimated
>        that 1,000,000 to 2,000,000 American women have received
>        silicone breast implants over the last 35 years.
>     (2) Silicone breast implants have been used primarily for
>        breast augmentation, but also as an important part of
>        reconstruction surgery for breast cancer or other conditions.
>            (3) Women with breast cancer or other medical conditions
>        seek access to the broadest possible treatment options,
>        including silicone breast implants.
>            (4) Women need complete and accurate information about the
>        potential health risks and advantages of silicone breast
>        implants so that women can make informed decisions.
>            (5) Although the rate of implant rupture and silicone
>        leakage has not been definitively established, estimates are as
>        high as 70 percent.
>            (6) According to a 1997 Mayo Clinic study, 1 in 4 women
>        required additional surgery because of their implants within 5
>        years of receiving them.
>            (7) In addition to potential systemic complications, local
>        changes in breast tissue such as hardening, contraction of scar
>        tissue surrounding implants, blood clots, severe pain, burning
>        rashes, serious inflammation, or other complications requiring
>        surgical intervention following implantation have been
>        reported.
>            (8) According to the Institute of Medicine, concern remains
>        that exposure to silicone or other components in silicone
>        breast implants may result in currently undefined connective
>        tissue or autoimmune diseases.
>            (9) A group of independent scientists and clinicians
>        convened by the National Institute of Arthritis and
>        Musculoskeletal and Skin Diseases in April of 1997 addressed
>        concerns that an association may exist between atypical
>        connective tissue disease and silicone breast implants, and
>        called for additional basic research on the components of
>        silicone as well as biological responses to silicone.
>            (10) According to many reports, including a study published
>        in the Journal of the National Cancer Institute, the presence
>        of silicone breast implants may create difficulties in
>        obtaining complete mammograms.
>            (11) According to a 1995 Food and Drug Administration
>        publication, although silicone breast implants usually do not
>        interfere with a woman’s ability to nurse, if the implants
>        leak, there is some concern that the silicone may harm the
>        baby. Some studies suggest a link between breast feeding with
>        implants and problems with the child’s esophagus.
>    (b) Purpose.–It is the purpose of this Act to promote research to
>identify and evaluate the health effects of silicone breast implants,
>and to ensure that women and their doctors receive accurate information
>about such implants.
>    (c) Rule of Construction.–Nothing in this Act shall be construed
>to affect any rule or regulation promulgated under the authority of the
>Food, Drug and Cosmetic Act that is in effect on the date of enactment
>of this Act relating to the availability of silicone breast implants
>for reconstruction after mastectomy, correction of congenital
>deformities, or replacement for ruptured silicone implants for


>    Part H of title IV of the Public Health Service Act (42 U.S.C. 289
>et seq.) is amended by adding at the end the following:


>    “(a) Institute-Wide Coordinator.–The Director of NIH shall
>appoint an appropriate official of the Department of Health and Human
>Services to serve as the National Institutes of Health coordinator
>regarding silicone breast implant research. Such coordinator shall
>encourage and coordinate the participation of all appropriate
>Institutes in research on silicone breast implants, including–
>            “(1) the National Institute of Allergy and Infectious
>        Diseases;
>            “(2) the National Institute of Arthritis and
>        Musculoskeletal and Skin Diseases;
>            “(3) the National Institute of Child Health and Human
>        Development;
>            “(4) the National Institute of Environmental Health
>        Sciences;
>            “(5) the National Institute of Neurological Disorders and
>        Stroke; and
>            “(6) the National Cancer Institute.
>    “(b) Study Sections.–The Director of NIH shall establish a study
>section or special emphasis panel if determined to be appropriate, for
>the National Institutes of Health to review extramural research grant
>applications regarding silicone breast implants to ensure the
>appropriate design and high quality of such research and shall take
>appropriate action to ensure the quality of intramural research
>    “(c) Clinical Study.–
>            “(1) In general.–The Director of NIH shall conduct or
>        support research to expand the understanding of the health
>        implications of silicone breast implants. Such research should,
>        if determined to be scientifically appropriate, include a
>        multidisciplinary, clinical, case-controlled study of women
>        with silicone breast implants. Such a study should involve
>        women who have had such implants in place for at least 8 years,
>        focus on atypical disease presentation, neurological
>        dysfunction, and immune system irregularities, and evaluate to
>        what extent if any, their health differs from that of suitable
>        controls, including women with saline implants as a subset.
>            “(2) Annual report.–The Director of NIH shall annually
>        prepare and submit to the appropriate Committees of Congress a
>        report concerning the results of the study conducted under
>        paragraph (1).”.


>    To assist women and doctors in receiving accurate and complete
>information about the risks of silicone breast implants, the
>Commissioner on Food and Drugs shall–
>            (1) ensure that the toll-free Consumer Information Line and
>        materials concerning breast implants provided by the Food and
>        Drug Administration are available, up to date, and responsive
>        to reports of problems with silicone breast implants, and that
>        timely aggregate data concerning such reports shall be made
>        available to the public upon request and consistent with
>        existing confidentiality standards;
>            (2) revise the Administration’s breast implant information
>        update to clarify the procedure for reporting problems with
>        silicone implants or with the conduct of adjunct studies, and
>        specifically regarding the use of the Medwatch reporting
>        program;
>            (3) require that manufacturers of silicone breast implants
>        update implant package inserts and informed consent documents
>        regularly to reflect accurate information about such implants,
>        particularly the rupture rate of such implants; and
>            (4) require that any manufacturer of such implants that is
>        conducting an adjunct study on silicone breast implants–
>                    (A) amend such study protocol and informed consent
>                document to reflect that patients must be provided with
>                a copy of informed consent documents at the initial, or
>                earliest possible, consultation regarding breast
>                prosthesis;
>                    (B) amend the informed consent to inform women
>                about how to obtain a Medwatch form and encourage any
>                woman who withdraws from the study, or who would like
>                to report a problem, to submit a Medwatch form to
>                report such problem or concerns with the study and
>                reasons for withdrawing; and
>                    (C) amend the informed consent document to provide
>                potential participants with the inclusion criteria for
>                the clinical trial and the toll-free Consumer
>                Information number.


>    (a) Establishment.–There is established an interagency committee,
>to be known as the President’s Interagency Committee on Silicone Breast
>Implants (referred to in this Act as the “Committee”), to ensure the
>strategic management, communication, and oversight of the policy
>formation, research, and activities of the Federal Government regarding
>silicone breast implants.
>    (b) Composition.–The Committee shall be composed of–
>            (1) an individual to be appointed by the President who
>        represents the White House domestic policy staff;
>            (2) a representative, to be appointed by the Secretary of
>        Health and Human Services, from–
>                    (A) the Office of Women’s Health at the Department
>                of Health and Human Services;
>                    (B) the National Institutes of Health;
>                    (C) the Food and Drug Administration; and
>                    (D) the Centers for Disease Control and Prevention;
>            (3) a representative of the Department of Defense with
>        experience in the Department’s breast cancer research program;
>            (4) representatives of any other agencies deemed necessary
>        to accomplish the mission of the Committee, including the
>Social Security Administration if appropriate;
>            (5) up to 4 individuals to be appointed by the President
>        from scientists with established credentials and publications
>        in the area of silicone breast implants; and
>            (6) 2 women who have or have had silicone breast implants
>        to be appointed by the President.
>    (c) Chairperson.–
>            (1) In general.–The individual appointed under subsection
>        (b)(2)(A), or other official if the President determines that
>        such other official is more appropriate, shall service as the
>        chairperson of the Committee.
>            (2) Duties.–The chairperson of the Committee shall–
>                    (A) not less than twice each year, convene meetings
>                of the Committee; and
>                    (B) compile information for the consideration of
>                the full Committee at such meetings.
>    (d) Meetings.–The meetings of the Committee shall be open to the
>public and public witnesses shall be given the opportunity to speak and
>make presentations at such meetings. Each member of the Committee shall
>make a presentation to the full Committee at each such meeting
>concerning the activities conducted by such member or by the entity
>that such member is representing related to silicone breast implants.
>    (e) Administrative Provisions.–
>            (1) Terms and vacancies.–A member of the Committee shall
>        serve for a term of 2 or 4 years (rotating terms). A member may
>        be reappointed 2 times, but shall not exceed 8 years of
>        service. Any vacancy in the membership of the Committee shall
>        be filled in the manner in which the original appointment was
>        made and shall not affect the power of the remaining members to
>        carry out the duties of the Committee.
>            (2) Compensation; reimbursement of expenses.–Members of
>        the Committee may not receive compensation for service on the
>        Committee. Such members may, in accordance with chapter 57 of
>        title 5, United States Code, be reimbursed for travel,
>        subsistence, and other necessary expenses incurred in carrying
>        out the duties of the Committee.
>            (3) Staff; administrative support.–The Secretary of Health
>        and Human Services shall, on a reimbursable basis, provide to
>        the Committee such staff, administrative support, and other
>        assistance as may be necessary for the Committee to effectively
>        carry out the duties under this section.
>            (4) Conflict of interest.–The members of the Committee
>        shall not be in violation of any Federal conflict of interest
>        laws.
>    (f) Authorization of Appropriations.–There are authorized to be
>appropriated such sums as may be necessary to carry out this section.
>                                 <all>

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Re: Drive any new car for $100 p/month.

Has anyone looked into this? Sounds a little to good to be true…If so, please
reply to grah…, your help is appreciated.


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