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Archive for January, 2013

malaria/ferritin/STR

I few months back I was reading an article which spoke to a study which
had determined the health of people in Haiti.
One high report was ferritin .. was on average around 300 or so.

I contacted someone who is quite well known as to this fact and he told me
since the serum transferrin receptor levels are high in the study then
this was the gold standard which diagnosed lack of iron.. going against
what could be SEEN .. high ferritin.

It stuck in my craw ..

So it seems .. EVEN THOUGH there is high transferrin receptor .. there may
still be high iron.

Iron is KNOWN to feed malaria.
Those with high iron stores cannot shake malaria.

So in Haiti .. as most likely every other country .. the gold standard
cannot be used to diagnose .. iron deficiency.

   Haematologica 1999 Oct;84(10):869-73

Serum transferrin receptor levels are increased in asymptomatic and mild
Plasmodium falciparum-infection.

    Mockenhaupt FP, May J, Stark K, Falusi AG, Meyer CG, Bienzle U

   Institut fur Tropenmedizin, Spandauer Damm 130, 14050 Berlin, Germany.
   frank.mockenha…@charite.de

   BACKGROUND AND OBJECTIVE: The serum transferrin receptor (sTfR)
   concentration in an individual reflects the extent of erythropoietic
   activity and is considered a useful marker of iron deficiency
   independent of concurrent inflammation or infection. However, data on
   the impact of malaria on this parameter are ambiguous. We have
   examined potential associations of asymptomatic and mild Plasmodium
   falciparum-infections and of several erythrocyte variants with sTfR
   values in South West Nigeria. DESIGN AND METHODS: In a cross-sectional
   study among 161 non-hospitalized children, sTfR concentrations and P.
   falciparum parasitemia were assessed. In addition, hemoglobin (Hb) and
   serum ferritin values, Hb-types, glucose-6-phosphate dehydrogenase
   (G6PD)deficiency and a-globin genotypes were determined and the
   effects of these factors on sTfR levels were analyzed by univariate
   and multivariate statistical methods. RESULTS: P. falciparum-infection
   was present in 77% of the children. Mean sTfR levels were higher in
   infected than in non-infected children (geometric mean, 3.68, 95%
   confidence interval [3.5-3.9] vs. 2.99 [2.7-3.3] mg/L; p = 0.0009).
   There was a significant trend for higher sTfR values with increasing
   parasite density. sTfR values decreased continuously with age.
   Hb-types, G6PD-, and a-globin genotypes did not correlate with sTfR
   levels. In the multivariate analysis, age, Hb and log ferritin values,
   and parasite density of P. falciparum were independently associated
   with log sTfR values. INTERPRETATION AND CONCLUSIONS: sTfR
   concentrations are increased in asymptomatic and mild P.
   falciparum-infections suggesting adequate bone marrow response in this
   condition. The diagnostic value of sTfR levels for iron deficiency may
   be impaired in areas where stable malaria occurs.

   PMID: 10509032, UI: 99439731
     _________________________________________________________________

   Save the above report in [Macintosh] [Text] format
   Order documents on this page through Loansome Doc
     _________________________________________________________________

Who loves ya.
Tom

Jesus was a Vegetarian! http://www.nucleus.com/watchman
Moses was a Mystic! http://www.nucleus.com/watchman/light.html

.
posted by admin in Uncategorized and have Comments (3)

recurrence LIPOSARCOMA HELP

Hello,
I write from France,
my mom has had a retroperitoneal’ liposarcoma  well differenciated  since
1979. She has had 16 surgeries. no radiation, no chemotherapy.

she is very tired
someone knows any effective treatment to stop reccurence
thank you in advance

I am a list member of Sarcoma-Med but I don’t write often. I am french and
my english is not good.
You can
join it as well as the Liposarcoma support group(L-Sarcoma)  Put in this
web-site and you will get all the ACOR listings for support groups.
http://www.acor.org

bye bye
thanks in advance
Nicole from France
thier…@noos.fr


thier…@noos.fr      Nicole CHATELAIN

posted by admin in Uncategorized and have No Comments

malaria/ferritin/STR

I few months back I was reading an article which spoke to a study which
had determined the health of people in Haiti.
One high report was ferritin .. was on average around 300 or so.

I contacted someone who is quite well known as to this fact and he told me
since the serum transferrin receptor levels are high in the study then
this was the gold standard which diagnosed lack of iron.. going against
what could be SEEN .. high ferritin.

It stuck in my craw ..

So it seems .. EVEN THOUGH there is high transferrin receptor .. there may
still be high iron.

Iron is KNOWN to feed malaria.
Those with high iron stores cannot shake malaria.

So in Haiti .. as most likely every other country .. the gold standard
cannot be used to diagnose .. iron deficiency.

   Haematologica 1999 Oct;84(10):869-73

Serum transferrin receptor levels are increased in asymptomatic and mild
Plasmodium falciparum-infection.

    Mockenhaupt FP, May J, Stark K, Falusi AG, Meyer CG, Bienzle U

   Institut fur Tropenmedizin, Spandauer Damm 130, 14050 Berlin, Germany.
   frank.mockenha…@charite.de

   BACKGROUND AND OBJECTIVE: The serum transferrin receptor (sTfR)
   concentration in an individual reflects the extent of erythropoietic
   activity and is considered a useful marker of iron deficiency
   independent of concurrent inflammation or infection. However, data on
   the impact of malaria on this parameter are ambiguous. We have
   examined potential associations of asymptomatic and mild Plasmodium
   falciparum-infections and of several erythrocyte variants with sTfR
   values in South West Nigeria. DESIGN AND METHODS: In a cross-sectional
   study among 161 non-hospitalized children, sTfR concentrations and P.
   falciparum parasitemia were assessed. In addition, hemoglobin (Hb) and
   serum ferritin values, Hb-types, glucose-6-phosphate dehydrogenase
   (G6PD)deficiency and a-globin genotypes were determined and the
   effects of these factors on sTfR levels were analyzed by univariate
   and multivariate statistical methods. RESULTS: P. falciparum-infection
   was present in 77% of the children. Mean sTfR levels were higher in
   infected than in non-infected children (geometric mean, 3.68, 95%
   confidence interval [3.5-3.9] vs. 2.99 [2.7-3.3] mg/L; p = 0.0009).
   There was a significant trend for higher sTfR values with increasing
   parasite density. sTfR values decreased continuously with age.
   Hb-types, G6PD-, and a-globin genotypes did not correlate with sTfR
   levels. In the multivariate analysis, age, Hb and log ferritin values,
   and parasite density of P. falciparum were independently associated
   with log sTfR values. INTERPRETATION AND CONCLUSIONS: sTfR
   concentrations are increased in asymptomatic and mild P.
   falciparum-infections suggesting adequate bone marrow response in this
   condition. The diagnostic value of sTfR levels for iron deficiency may
   be impaired in areas where stable malaria occurs.

   PMID: 10509032, UI: 99439731
     _________________________________________________________________

   Save the above report in [Macintosh] [Text] format
   Order documents on this page through Loansome Doc
     _________________________________________________________________

Who loves ya.
Tom

Jesus was a Vegetarian! http://www.nucleus.com/watchman
Moses was a Mystic! http://www.nucleus.com/watchman/light.html

posted by admin in Uncategorized and have Comments (3)

recurrence LIPOSARCOMA HELP

Hello,
I write from France,
my mom has had a retroperitoneal’ liposarcoma  well differenciated  since
1979. She has had 16 surgeries. no radiation, no chemotherapy.

she is very tired
someone knows any effective treatment to stop reccurence
thank you in advance

I am a list member of Sarcoma-Med but I don’t write often. I am french and
my english is not good.
You can
join it as well as the Liposarcoma support group(L-Sarcoma)  Put in this
web-site and you will get all the ACOR listings for support groups.
http://www.acor.org

bye bye
thanks in advance
Nicole from France
thier…@noos.fr


thier…@noos.fr      Nicole CHATELAIN

posted by admin in Uncategorized and have No Comments

fever, UTI, tried levaquin

I’m not a doctor, and I have recently been puzzled about a condition I’m
going through.  I have gone to a local, general practitioner, and still lack
confidence knowing what it is.  It started with slight discomfort on the
left side (kidney area), and blood in the urine.  When I say I have that,
it’s because of the visible redness.  That was about 3 weeks ago.  I’m used
to this over the past 6 or 8 years from when a good-sized kidney stone is
heading down.  So I’ve peed red about 3 to 5 times altogether in that
period.

A few weeks ago, I got a little freaked out by something I haven’t seen
before – visible organic material coming out in my urine.  White tissue-like
material with redness – pieces a half inch or more in length.  I leave it in
a glass, and the redness fades in a few hours, and the white material
dissolves in one to three days.  This has happens 8 or 10 times in this
period.

The doctor prescribed levaquin after my giving a urine sample.  He found
clumps of white blood cells.  I took one 500 Mg tablet a day for 10 days.
On about the 9th day, I started to experience symptoms I hadn’t before, also
of which he expected me to have when I first visited.  These included fever,
aches, tiredness.  I continue to experience the fever, and urination is a
bit uncomfortable.  I sleep quite a bit at this point.

Two days ago, I started a fast.  I’m calling it "plan B".  It’s been about
56 hours.  The discomfort on the left side is still there, the fever doesn’t
budge.  The last time I licked a UTI was in ’94, and I did it then by
nothing but cranberry juice and water for 48 hours.  So I’m starting to get
concerned as to whether or not continuing to fast is going to kill this
bugger, if it is a bugger, in my system.

Any comments?  Haven’t seen any responses regarding "tissue in urine" post
from previously (sci.med.pathology).

posted by admin in Uncategorized and have Comments (14)

malaria/ferritin/STR

I few months back I was reading an article which spoke to a study which
had determined the health of people in Haiti.
One high report was ferritin .. was on average around 300 or so.

I contacted someone who is quite well known as to this fact and he told me
since the serum transferrin receptor levels are high in the study then
this was the gold standard which diagnosed lack of iron.. going against
what could be SEEN .. high ferritin.

It stuck in my craw ..

So it seems .. EVEN THOUGH there is high transferrin receptor .. there may
still be high iron.

Iron is KNOWN to feed malaria.
Those with high iron stores cannot shake malaria.

So in Haiti .. as most likely every other country .. the gold standard
cannot be used to diagnose .. iron deficiency.

   Haematologica 1999 Oct;84(10):869-73

Serum transferrin receptor levels are increased in asymptomatic and mild
Plasmodium falciparum-infection.

    Mockenhaupt FP, May J, Stark K, Falusi AG, Meyer CG, Bienzle U

   Institut fur Tropenmedizin, Spandauer Damm 130, 14050 Berlin, Germany.
   frank.mockenha…@charite.de

   BACKGROUND AND OBJECTIVE: The serum transferrin receptor (sTfR)
   concentration in an individual reflects the extent of erythropoietic
   activity and is considered a useful marker of iron deficiency
   independent of concurrent inflammation or infection. However, data on
   the impact of malaria on this parameter are ambiguous. We have
   examined potential associations of asymptomatic and mild Plasmodium
   falciparum-infections and of several erythrocyte variants with sTfR
   values in South West Nigeria. DESIGN AND METHODS: In a cross-sectional
   study among 161 non-hospitalized children, sTfR concentrations and P.
   falciparum parasitemia were assessed. In addition, hemoglobin (Hb) and
   serum ferritin values, Hb-types, glucose-6-phosphate dehydrogenase
   (G6PD)deficiency and a-globin genotypes were determined and the
   effects of these factors on sTfR levels were analyzed by univariate
   and multivariate statistical methods. RESULTS: P. falciparum-infection
   was present in 77% of the children. Mean sTfR levels were higher in
   infected than in non-infected children (geometric mean, 3.68, 95%
   confidence interval [3.5-3.9] vs. 2.99 [2.7-3.3] mg/L; p = 0.0009).
   There was a significant trend for higher sTfR values with increasing
   parasite density. sTfR values decreased continuously with age.
   Hb-types, G6PD-, and a-globin genotypes did not correlate with sTfR
   levels. In the multivariate analysis, age, Hb and log ferritin values,
   and parasite density of P. falciparum were independently associated
   with log sTfR values. INTERPRETATION AND CONCLUSIONS: sTfR
   concentrations are increased in asymptomatic and mild P.
   falciparum-infections suggesting adequate bone marrow response in this
   condition. The diagnostic value of sTfR levels for iron deficiency may
   be impaired in areas where stable malaria occurs.

   PMID: 10509032, UI: 99439731
     _________________________________________________________________

   Save the above report in [Macintosh] [Text] format
   Order documents on this page through Loansome Doc
     _________________________________________________________________

Who loves ya.
Tom

Jesus was a Vegetarian! http://www.nucleus.com/watchman
Moses was a Mystic! http://www.nucleus.com/watchman/light.html

posted by admin in Uncategorized and have Comments (3)

recurrence LIPOSARCOMA HELP

Hello,
I write from France,
my mom has had a retroperitoneal’ liposarcoma  well differenciated  since
1979. She has had 16 surgeries. no radiation, no chemotherapy.

she is very tired
someone knows any effective treatment to stop reccurence
thank you in advance

I am a list member of Sarcoma-Med but I don’t write often. I am french and
my english is not good.
You can
join it as well as the Liposarcoma support group(L-Sarcoma)  Put in this
web-site and you will get all the ACOR listings for support groups.
http://www.acor.org

bye bye
thanks in advance
Nicole from France
thier…@noos.fr


thier…@noos.fr      Nicole CHATELAIN

posted by admin in Uncategorized and have No Comments

fever, UTI, tried levaquin

I’m not a doctor, and I have recently been puzzled about a condition I’m
going through.  I have gone to a local, general practitioner, and still lack
confidence knowing what it is.  It started with slight discomfort on the
left side (kidney area), and blood in the urine.  When I say I have that,
it’s because of the visible redness.  That was about 3 weeks ago.  I’m used
to this over the past 6 or 8 years from when a good-sized kidney stone is
heading down.  So I’ve peed red about 3 to 5 times altogether in that
period.

A few weeks ago, I got a little freaked out by something I haven’t seen
before – visible organic material coming out in my urine.  White tissue-like
material with redness – pieces a half inch or more in length.  I leave it in
a glass, and the redness fades in a few hours, and the white material
dissolves in one to three days.  This has happens 8 or 10 times in this
period.

The doctor prescribed levaquin after my giving a urine sample.  He found
clumps of white blood cells.  I took one 500 Mg tablet a day for 10 days.
On about the 9th day, I started to experience symptoms I hadn’t before, also
of which he expected me to have when I first visited.  These included fever,
aches, tiredness.  I continue to experience the fever, and urination is a
bit uncomfortable.  I sleep quite a bit at this point.

Two days ago, I started a fast.  I’m calling it "plan B".  It’s been about
56 hours.  The discomfort on the left side is still there, the fever doesn’t
budge.  The last time I licked a UTI was in ’94, and I did it then by
nothing but cranberry juice and water for 48 hours.  So I’m starting to get
concerned as to whether or not continuing to fast is going to kill this
bugger, if it is a bugger, in my system.

Any comments?  Haven’t seen any responses regarding "tissue in urine" post
from previously (sci.med.pathology).

posted by admin in Uncategorized and have Comments (14)

malaria/ferritin/STR

I few months back I was reading an article which spoke to a study which
had determined the health of people in Haiti.
One high report was ferritin .. was on average around 300 or so.

I contacted someone who is quite well known as to this fact and he told me
since the serum transferrin receptor levels are high in the study then
this was the gold standard which diagnosed lack of iron.. going against
what could be SEEN .. high ferritin.

It stuck in my craw ..

So it seems .. EVEN THOUGH there is high transferrin receptor .. there may
still be high iron.

Iron is KNOWN to feed malaria.
Those with high iron stores cannot shake malaria.

So in Haiti .. as most likely every other country .. the gold standard
cannot be used to diagnose .. iron deficiency.

   Haematologica 1999 Oct;84(10):869-73

Serum transferrin receptor levels are increased in asymptomatic and mild
Plasmodium falciparum-infection.

    Mockenhaupt FP, May J, Stark K, Falusi AG, Meyer CG, Bienzle U

   Institut fur Tropenmedizin, Spandauer Damm 130, 14050 Berlin, Germany.
   frank.mockenha…@charite.de

   BACKGROUND AND OBJECTIVE: The serum transferrin receptor (sTfR)
   concentration in an individual reflects the extent of erythropoietic
   activity and is considered a useful marker of iron deficiency
   independent of concurrent inflammation or infection. However, data on
   the impact of malaria on this parameter are ambiguous. We have
   examined potential associations of asymptomatic and mild Plasmodium
   falciparum-infections and of several erythrocyte variants with sTfR
   values in South West Nigeria. DESIGN AND METHODS: In a cross-sectional
   study among 161 non-hospitalized children, sTfR concentrations and P.
   falciparum parasitemia were assessed. In addition, hemoglobin (Hb) and
   serum ferritin values, Hb-types, glucose-6-phosphate dehydrogenase
   (G6PD)deficiency and a-globin genotypes were determined and the
   effects of these factors on sTfR levels were analyzed by univariate
   and multivariate statistical methods. RESULTS: P. falciparum-infection
   was present in 77% of the children. Mean sTfR levels were higher in
   infected than in non-infected children (geometric mean, 3.68, 95%
   confidence interval [3.5-3.9] vs. 2.99 [2.7-3.3] mg/L; p = 0.0009).
   There was a significant trend for higher sTfR values with increasing
   parasite density. sTfR values decreased continuously with age.
   Hb-types, G6PD-, and a-globin genotypes did not correlate with sTfR
   levels. In the multivariate analysis, age, Hb and log ferritin values,
   and parasite density of P. falciparum were independently associated
   with log sTfR values. INTERPRETATION AND CONCLUSIONS: sTfR
   concentrations are increased in asymptomatic and mild P.
   falciparum-infections suggesting adequate bone marrow response in this
   condition. The diagnostic value of sTfR levels for iron deficiency may
   be impaired in areas where stable malaria occurs.

   PMID: 10509032, UI: 99439731
     _________________________________________________________________

   Save the above report in [Macintosh] [Text] format
   Order documents on this page through Loansome Doc
     _________________________________________________________________

Who loves ya.
Tom

Jesus was a Vegetarian! http://www.nucleus.com/watchman
Moses was a Mystic! http://www.nucleus.com/watchman/light.html

posted by admin in Uncategorized and have Comments (3)

recurrence LIPOSARCOMA HELP

Hello,
I write from France,
my mom has had a retroperitoneal’ liposarcoma  well differenciated  since
1979. She has had 16 surgeries. no radiation, no chemotherapy.

she is very tired
someone knows any effective treatment to stop reccurence
thank you in advance

I am a list member of Sarcoma-Med but I don’t write often. I am french and
my english is not good.
You can
join it as well as the Liposarcoma support group(L-Sarcoma)  Put in this
web-site and you will get all the ACOR listings for support groups.
http://www.acor.org

bye bye
thanks in advance
Nicole from France
thier…@noos.fr


thier…@noos.fr      Nicole CHATELAIN

posted by admin in Uncategorized and have No Comments