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Alcohol and Iron

Semin Liver Dis. 2004 Aug;24(3):317-325.  Related Articles, Links  

Alcohol and Iron.

Tavill AS, Qadri AM.

Professor of Medicine and Nutrition; Consultant Hepatologist.

Iron in its free ferrous and ferric states may serve as a physiological
regulator of normal intracellular functions but can be a double-edged sword
when linked to several pathways of cellular toxicity. In particular, oxidative
stress-induced cytotoxicity leading to both necrosis and apoptosis (so-called
necrapoptosis) may be promoted by increased intracellular free iron. When
hepatocyte iron accumulates to excess in clinical alcohol abuse or in an
experimental, combined model of iron and alcohol hepatotoxicity, there is
evidence for synergy among the putative pathways of oxidative stress. Just how
excess hepatocyte iron accumulates in alcohol excess is unknown, but when the
usual safe harbor for intracellular iron, namely the endosomal-lysosomal
compartment, is compromised, it becomes a potent source of free, chelatable
pro-oxidant iron. In this regard excess iron in alcohol-induced liver damage
and alcohol excess in iron-overload disease are powerful cocktails promoting
subcellular organelle damage leading to cell death and fibrogenesis. In some
experimental circumstances, only the combined insults of both alcohol and iron
overload are capable of inducing cell injury and fibrogenesis. There are
clinical examples for such relative resistance to each hepatotoxin presented to
the liver in isolation that lend support to this concept of synergy of
pro-oxidant pathways of liver injury.

PMID: 15349808 [PubMed - as supplied by publisher]

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Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

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One Response to “Alcohol and Iron”

  1. admin says:

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    >Subject: Alcohol and Iron
    >From: ironjust…@aol.comdoe  (doe)
    >Date: 9/7/2004 9:18 AM Mountain Daylight Time
    >Message-id: <20040907111844.04845.00002…@mb-m24.aol.com>

    >Semin Liver Dis. 2004 Aug;24(3):317-325.  Related Articles, Links  

    >Alcohol and Iron.

    >Tavill AS, Qadri AM.

    >Professor of Medicine and Nutrition; Consultant Hepatologist.

    >Iron in its free ferrous and ferric states may serve as a physiological
    >regulator of normal intracellular functions but can be a double-edged sword
    >when linked to several pathways of cellular toxicity. In particular,
    >oxidative
    >stress-induced cytotoxicity leading to both necrosis and apoptosis (so-called
    >necrapoptosis) may be promoted by increased intracellular free iron. When
    >hepatocyte iron accumulates to excess in clinical alcohol abuse or in an
    >experimental, combined model of iron and alcohol hepatotoxicity, there is
    >evidence for synergy among the putative pathways of oxidative stress. Just
    >how
    >excess hepatocyte iron accumulates in alcohol excess is unknown, but when the
    >usual safe harbor for intracellular iron, namely the endosomal-lysosomal
    >compartment, is compromised, it becomes a potent source of free, chelatable
    >pro-oxidant iron. In this regard excess iron in alcohol-induced liver damage
    >and alcohol excess in iron-overload disease are powerful cocktails promoting
    >subcellular organelle damage leading to cell death and fibrogenesis. In some
    >experimental circumstances, only the combined insults of both alcohol and
    >iron
    >overload are capable of inducing cell injury and fibrogenesis. There are
    >clinical examples for such relative resistance to each hepatotoxin presented
    >to
    >the liver in isolation that lend support to this concept of synergy of
    >pro-oxidant pathways of liver injury.

    >PMID: 15349808 [PubMed - as supplied by publisher]

    >————————————————————————–
    >——

    http://tinyurl.com/4vjpl

    Hepatic Iron Deprivation Prevents Spontaneous Development of Fulminant
    Hepatitis and Liver Cancer in Long-Evans Cinnamon Rats

    >Who loves ya.
    >Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking