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AZT — The Generation Terminator

The following was released this A.M. (9/4/97) at the
Conference on Global Strategies for the prevention of HIV
Transmission from Mothers to Infants. September 3-6, 1997

The conclusion:

   "These studies demonstrate that AZT is a moderately-strong
    transplacental carcinogen in mice, and is readily incorporated
    into tissue DNA of both mouse and human fetuses exposed
    in utero."

I have learned from researchers at the National Cancer
Institute that this information has been known for quite some
time. However, many months ago, I was informed that the
management of the NCI had intended to prevent the release
of this information that, to say the least, reveals some
rather disturbing implications for the children born to
mothers on AZT. While AZT is a known DNA chain terminator,
when used in pregnant mothers, it also appears to be an
effective generation terminator as well.

The mouse studies of AZT involved doses not exceeding therapeutic
levels. The offspring developed a "multiplicity" of tumors
among the various tissue systems mentioned below. In personal
NCI communications, these tumors were reported to emerge
prior to the equivalent human age of 20-30 years.

There has been no response to date from the National Institute
of Allergy and Infectious Diseases. NIAID was involved in
the original AZT/maternal transmission study that had been
stopped early due to its rather dramatic "findings".

============

AZT IS A POTENTIAL TRANSPLACENTAL CARCINOGEN

O.A. Olivero (1), L. M. Anderson (2), B.A. Diwan (3), D.C.
Haines (3), J. M Rice (4), C. W. Riggs (3), G. M. Shearer (1),
C.A. Chougnet (1), A. Kovacs (5), S.H. Yuspa (1), and M. C.
Poirier (1).

1. NCI, Bethesda MD 20892, 2. NCI, Frederick MD 21702, 3-5 USC,
Los Angeles, CA, 90033,

AZT therapy significantly reduces maternal-fetal transmission
of HIV-1 in pregnant women and thereby protects ~1400 children
per year in the United States alone. Transplacental
tumorigenicity and genotoxicity studies in animal models were
designed to explore potential toxic effects of AZT in the
fetuses of pregnant CD-1 mice. These were compared to AZT
genotoxicity in infants of pregnant HIV-1 positive mothers.
Pregnant CD-1 mice were given daily oral doses of 12.5 and 25.0
mg AZT on days 12-18 of gestation for a total dose of about 3.5
gm AZT/kg body weight. Multiple organs of newborn mice were
examined for AZT incorporation into DNA. Additional offspring,
grown to adulthood, had 2 to 8 fold (statistically significant)
increases in incidences and multiplicities of lung, liver and
female reproductive organ tumors at one year of age. In newborn
mice, levels of AZT incorporated into nuclear and mitochondrial
DNA of brain, lung, liver, kidney and skin varied from
nondetectable to 75/10^6 nucleotides. In addition, shortening
of telomere length was observed in DNA of livers, brains and
lungs from most AZT-exposed litters. Pregnant HIV-1 positive
women receive 500-600 mg AZT/day during weeks 14-38 of
pregnancy for a total dose of about 1.4 gm AZT/kg body weight.
In these studies cord blood was obtained at delivery from
infants of 5 HIV-positive women and 4 HIV-negative women. Four
of the HIV-positive women received AZT therapy for 3-7 months,
and 3 of these infants had AZT incorporated into cord blood DNA
at levels of 23-67/10^6 nucleotides, while the fourth had
<6/10^6 nucleotides. These studies demonstrate that AZT is a
moderately-strong transplacental carcinogen in mice, and is
readily incorporated into tissue DNA of both mouse and human
fetuses exposed in utero.

.
posted by admin in Uncategorized and have Comments (2)

2 Responses to “AZT — The Generation Terminator”

  1. admin says:

    In article <340F3C7F.1…@primenet.com>, freds…@primenet.com says…

    >female reproductive organ tumors at one year of age. In newborn
    >mice, levels of AZT incorporated into nuclear and mitochondrial
    >DNA of brain, lung, liver, kidney and skin varied from
    >nondetectable to 75/10^6 nucleotides. In addition, shortening

    What is worse. If it enters the newborn child’s DNA and mitochondrial DNA, it
    will also enter all the unripe, developing eggs of the mother, and modify both
    DNA (which may be somewhat recombined by the fathers genepool at fertilization)
    and the mitochondrial DNA (which cannot be recombined at fertilization time).

    That means, if the eggs affected by the AZT still developes, and is fertilized,
    the gene modifications of the DNA is being transferred to the child, and if a
    daughter, will be transferred to the grandchildren, greatgrandchildren, gggc
    etc. etc. And, if the mother is smoking too, even more mitochondrial DNA will
    be mutated and conservatedfor the rest of the time of that life line (until it
    stops once in a future when the mitochondrial DNA is so damaged that the
    fertilized egg cannot anymore be developed into a fertile mother who is
    fertilizing a new egg.
    By smoking, the mutation agents do about the same job as AZT. With males, it
    doesn’t bother, our mitochondries dies atfertilization time. With a young
    mother, by smoking before menopause, you affect your future grandchildren lifes
    in a rather bad way :-(


    ————————————–
    Alf Christophersen, Computer engineer
    URL: http://www.uio.no/~achristo

  2. admin says:

    Alf Christophersen wrote:
    > That means, if the eggs affected by the AZT still developes, and is fertilized,
    > the gene modifications of the DNA is being transferred to the child, and if a
    > daughter, will be transferred to the grandchildren, greatgrandchildren, gggc
    > etc. etc.

    Possible. However, when I say AZT is now a "generation terminator",
    it is likely that the children born to mothers on AZT will
    not escape their miserable, tumor-ridden short existence on
    this planet. By then, the doctors of the concentration camps
    will have passed the baton to their cubs in training today.
    Of course, the mothers will have passed on long before,
    and who knows where their kids, if the are HIV-, will end
    up — but you can bet a lot will disappear into the adoption
    game and the new parents will have no idea that they have
    adopted and invested their emotional existence in a
    cancer timebomb. So you see, the child is only the first
    victim — the victimization will expand outward exponentially
    and throughout the world. All because Glaxo needed to make
    a couple of bucks and Tony Fauci’s NIAID "research" henchmen
    designed their trial to find exactly what they wanted.

    But most telling, I learn more from those who don’t answer
    this post, than from those who do…

    fred

    And, if the mother is smoking too, even more mitochondrial DNA will

    - Hide quoted text — Show quoted text -

    > be mutated and conservatedfor the rest of the time of that life line (until it
    > stops once in a future when the mitochondrial DNA is so damaged that the
    > fertilized egg cannot anymore be developed into a fertile mother who is
    > fertilizing a new egg.
    > By smoking, the mutation agents do about the same job as AZT. With males, it
    > doesn’t bother, our mitochondries dies atfertilization time. With a young
    > mother, by smoking before menopause, you affect your future grandchildren lifes
    > in a rather bad way :-(

    > —
    > ————————————–
    > Alf Christophersen, Computer engineer
    > URL: http://www.uio.no/~achristo