Pathology and laboratory medicine

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CAP, re: LGL

Our most recent CAP hematology proficiency challenge included several
ungraded projection slides for differentiation of normal, atypical, and
large granular lymphocytes as well as plasmacytes and monocytes.

Over the past several years I have occasionally run across brief sections of
hematology texts concerning large granular lymphs.  Anyone routinely
performing WBC differentials has seen a few in clinical specimens.
Descriptions of both LGL’s themselves and a "Large Granular Lymphocytosis
(Syndrome)" vary from reference to reference.

I’m wondering if there is recent information pertaining to the clinical
signifigance of an occasional LGL in a "normal" blood or perhaps if new
information exists as to the pathology of the syndrome.  Any insight would
be appreciated.

Thanks,
Lee

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