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Digoxin and quercetin

Life Sci. 2004 Jan 23;74(10):1191-1197.  Links

Lethal quercetin-digoxin interaction in pigs.

Wang YH, Chao PD, Hsiu SL, Wen KC, Hou YC.

Institute of Pharmaceutical Chemistry, China Medical University, Taichung,
Taiwan

Digoxin is a popular cardiac glycoside with very narrow therapeutic range.
Quercetin is an ubiquitous antioxidant flavonoid. Digoxin is a substrate of
P-glycoprotein (P-gp), a multi-drug efflux transporter, and quercetin was
reported to be a modulator of P-gp. The aim of this study was to investigate
the effect of quercetin on the absorption and disposition of digoxin in pigs.
Pigs were orally given digoxin (0.02 mg/kg) with and without quercetin in
crossover designs. The blood was collected via jugular vein and fluorescence
polarization immunoassay was used to determine the serum concentration of
digoxin. The pharmacokinetic parameters were calculated using WINNONLIN. The
paired Student’s t-test was used for statistical comparison. The
coadministration of 50 mg/kg quercetin unexpectedly resulted in sudden death of
two among three pigs within 30 min after digoxin administration. The
coadministration of 40 mg/kg quercetin significantly elevated the C(max) of
digoxin by 413% and increased the AUC(0-t) by 170%. The results indicated that
a very serious pharmacokinetic interaction occurred between quercetin and
digoxin. The concomitant administration of digoxin and quercetin or
quercetin-containing herbs and dietary supplement should be avoided.

PMID: 14697403 [PubMed - as supplied by publisher]

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Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
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DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

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One Response to “Digoxin and quercetin”

  1. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Digoxin and quercetin
    >From: ironjust…@aol.comdoe  (doe)
    >Date: 12/31/2003 9:15 AM Mountain Standard Time
    >Message-id: <20031231111536.14410.00002…@mb-m28.aol.com>

    >Life Sci. 2004 Jan 23;74(10):1191-1197.  Links

    >Lethal quercetin-digoxin interaction in pigs.

    >Wang YH, Chao PD, Hsiu SL, Wen KC, Hou YC.

    >Institute of Pharmaceutical Chemistry, China Medical University, Taichung,
    >Taiwan

    >Digoxin is a popular cardiac glycoside with very narrow therapeutic range.
    >Quercetin is an ubiquitous antioxidant flavonoid. Digoxin is a substrate of
    >P-glycoprotein (P-gp), a multi-drug efflux transporter, and quercetin was
    >reported to be a modulator of P-gp. The aim of this study was to investigate
    >the effect of quercetin on the absorption and disposition of digoxin in pigs.
    >Pigs were orally given digoxin (0.02 mg/kg) with and without quercetin in
    >crossover designs. The blood was collected via jugular vein and fluorescence
    >polarization immunoassay was used to determine the serum concentration of
    >digoxin. The pharmacokinetic parameters were calculated using WINNONLIN. The
    >paired Student’s t-test was used for statistical comparison. The
    >coadministration of 50 mg/kg quercetin unexpectedly resulted in sudden death
    >of
    >two among three pigs within 30 min after digoxin administration. The
    >coadministration of 40 mg/kg quercetin significantly elevated the C(max) of
    >digoxin by 413% and increased the AUC(0-t) by 170%. The results indicated
    >that
    >a very serious pharmacokinetic interaction occurred between quercetin and
    >digoxin. The concomitant administration of digoxin and quercetin or
    >quercetin-containing herbs and dietary supplement should be avoided.

    >PMID: 14697403 [PubMed - as supplied by publisher]

    >————————————————————————–
    >——

    Is this ? .. could it NOT be this .. ? which is causing the contraindication in
    the use of grapefruit during times of use of medication .. ?

    Quercitin .. ?

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking