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free radicals in rheumatoid arthritis

Free Radic Res. 2004 Jun;38(6):623-8.  Related Articles, Links  

Oxidation of uric acid in rheumatoid arthritis: is allantoin a marker of
oxidative stress?

Yardim-Akaydin S, Sepici A, Ozkan Y, Torun M, Simsek B, Sepici V.

Department of Biochemistry, Faculty of Pharmacy, Gazi University 06330, Etiler,
Ankara, Turkey. sev…@gazi.edu.tr

Free radicals are implicated in many diseases including atherosclerosis, cancer
and also in rheumatoid arthritis. Reaction of uric acid with free radicals,
such as hydroxyl radical and hypochlorous acid (HOCl) results in allantoin
production. In this study, we measured the serum allantoin levels, oxidation
products of uric acid, as a marker of free radical generation in rheumatoid
arthritis. Fasting blood samples were obtained from 21 rheumatoid patients and
15 healthy controls. In this study, the serum allantoin and uric acid levels
were measured by a gas chromatography-mass spectrometry method and the ratios
were calculated. The mean allantoin and uric acid levels and ratios in the
patient group were 22.1 +/- 11.3, 280.5 +/- 65.0 and 8.0 +/- 3.7 microM, while
in the control group they were 13.6 +/- 6.3, 278.3 +/- 53.6 and 4.9 +/- 2.1
microM, respectively. The effects of gender, age, menopausal status, duration
of disease and medications on serum allantoin and uric acid levels of the
patient and control groups were studied. Our results suggest that uric acid
acts as a free radical scavenger and thus is converted to allantoin. Increased
allantoin levels suggest the possible involvement of free radicals in
rheumatoid arthritis.

PMID: 15346653 [PubMed - in process]

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