Pathology and laboratory medicine

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iron and cardiovascular disease

Stroke. 2004 Jan 15 [Epub ahead of print] Links

Association Between High Serum Ferritin Levels and Carotid Atherosclerosis in
the Study of Health in Pomerania (SHIP).

Wolff B, Volzke H, Ludemann J, Robinson D, Vogelgesang D, Staudt A, Kessler C,
Dahm JB, John U, Felix SB.

Klinik fur Innere Medizin B, Institut fur Epidemiologie und Sozialmedizin,
Institut fur Klinische Chemie, and Klinik fur Neurologie, Universitat
Greifswald, Greifswald, Germany.

BACKGROUND AND PURPOSE: Several studies have provided evidence for a
relationship between body iron load and cardiovascular disease. We analyzed the
association of serum ferritin levels with carotid atherosclerosis. METHODS: We
assessed intima-media thickness and plaque prevalence in the carotid arteries
by high-resolution ultrasound among 2443 participants (1200 women; age, 45 to
79 years) in the Study of Health in Pomerania (SHIP), a population-based study
in northeast Germany. RESULTS: In multivariate analysis, serum ferritin levels
were not independently associated with carotid intima-media thickness among
women or men. In contrast, the relationship between serum ferritin levels and
carotid plaque prevalence was significant among men (odds ratio per 1-SD
increase of serum ferritin levels, 1.33; 95% confidence interval, 1.08 to 1.44)
yet not among women (odds ratio, 1.29; 95% confidence interval, 0.98 to 1.75).
However, both men and women showed a dose-response relation between serum
ferritin levels and carotid atherosclerosis in which higher serum ferritin
levels were associated with greater odds ratios for carotid plaque prevalence.
Additionally, there was an interaction of serum ferritin levels with
low-density lipoprotein (LDL) cholesterol (P=0.039) among men in which the
association of serum ferritin levels with carotid plaque prevalence became
stronger with increasing LDL cholesterol levels. CONCLUSIONS: Our study
identified a relationship between serum ferritin levels and carotid
atherosclerosis that was potentiated by LDL cholesterol. This relationship adds
support to the hypothesis of a link between iron and cardiovascular disease.

PMID: 14726541 [PubMed - as supplied by publisher]

————————————————————————–
——

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

.
posted by admin in Uncategorized and have Comments (24)

24 Responses to “iron and cardiovascular disease”

  1. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040117113959.22897.00000209@mb-m04.aol.com…

    > Stroke. 2004 Jan 15 [Epub ahead of print] Links

    Don’t change the subject Tom – I’m still waiting for your answer ofver the
    child in extremis.

  2. admin says:

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/17/2004 10:41 AM Mountain Standard Time
    >Message-id: <bubs4m$gh…@newsg1.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040117113959.22897.00000209@mb-m04.aol.com…
    >> Stroke. 2004 Jan 15 [Epub ahead of print] Links

    >Don’t change the subject Tom – I’m still waiting for your answer ofver the
    >child in extremis.

    Don’t snip my thread ..

    Dig .. ?

    Stroke. 2004 Jan 15 [Epub ahead of print] Links

    Association Between High Serum Ferritin Levels and Carotid Atherosclerosis in
    the Study of Health in Pomerania (SHIP).

    Wolff B, Volzke H, Ludemann J, Robinson D, Vogelgesang D, Staudt A, Kessler C,
    Dahm JB, John U, Felix SB.

    Klinik fur Innere Medizin B, Institut fur Epidemiologie und Sozialmedizin,
    Institut fur Klinische Chemie, and Klinik fur Neurologie, Universitat
    Greifswald, Greifswald, Germany.

    BACKGROUND AND PURPOSE: Several studies have provided evidence for a
    relationship between body iron load and cardiovascular disease. We analyzed the
    association of serum ferritin levels with carotid atherosclerosis. METHODS: We
    assessed intima-media thickness and plaque prevalence in the carotid arteries
    by high-resolution ultrasound among 2443 participants (1200 women; age, 45 to
    79 years) in the Study of Health in Pomerania (SHIP), a population-based study
    in northeast Germany. RESULTS: In multivariate analysis, serum ferritin levels
    were not independently associated with carotid intima-media thickness among
    women or men. In contrast, the relationship between serum ferritin levels and
    carotid plaque prevalence was significant among men (odds ratio per 1-SD
    increase of serum ferritin levels, 1.33; 95% confidence interval, 1.08 to 1.44)
    yet not among women (odds ratio, 1.29; 95% confidence interval, 0.98 to 1.75).
    However, both men and women showed a dose-response relation between serum
    ferritin levels and carotid atherosclerosis in which higher serum ferritin
    levels were associated with greater odds ratios for carotid plaque prevalence.
    Additionally, there was an interaction of serum ferritin levels with
    low-density lipoprotein (LDL) cholesterol (P=0.039) among men in which the
    association of serum ferritin levels with carotid plaque prevalence became
    stronger with increasing LDL cholesterol levels. CONCLUSIONS: Our study
    identified a relationship between serum ferritin levels and carotid
    atherosclerosis that was potentiated by LDL cholesterol. This relationship adds
    support to the hypothesis of a link between iron and cardiovascular disease.

    PMID: 14726541 [PubMed - as supplied by publisher]

    ————————————————————————–
    ——

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  3. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040117140208.22644.00000118@mb-m18.aol.com…

    - Hide quoted text — Show quoted text -

    > >Subject: Re: iron and cardiovascular disease
    > >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    > >Date: 1/17/2004 10:41 AM Mountain Standard Time
    > >Message-id: <bubs4m$gh…@newsg1.svr.pol.co.uk>

    > >"doe" <ironjust…@aol.comdoe> wrote in message
    > >news:20040117113959.22897.00000209@mb-m04.aol.com…
    > >> Stroke. 2004 Jan 15 [Epub ahead of print] Links

    > >Don’t change the subject Tom – I’m still waiting for your answer ofver
    the
    > >child in extremis.

    > Don’t snip my thread ..

    Let’s worry about new stuff once the old has been sorted.

    Remember Tom – the more evasive you are, the less convincing your argument.

    MB

  4. admin says:

    >Subject: Re: iron and cardiovascular disease

    Stroke. 2004 Jan 15 [Epub ahead of print] Links

    Association Between High Serum Ferritin Levels and Carotid Atherosclerosis in
    the Study of Health in Pomerania (SHIP).

    Wolff B, Volzke H, Ludemann J, Robinson D, Vogelgesang D, Staudt A, Kessler C,
    Dahm JB, John U, Felix SB.

    Klinik fur Innere Medizin B, Institut fur Epidemiologie und Sozialmedizin,
    Institut fur Klinische Chemie, and Klinik fur Neurologie, Universitat
    Greifswald, Greifswald, Germany.

    BACKGROUND AND PURPOSE: Several studies have provided evidence for a
    relationship between body iron load and cardiovascular disease. We analyzed the
    association of serum ferritin levels with carotid atherosclerosis. METHODS: We
    assessed intima-media thickness and plaque prevalence in the carotid arteries
    by high-resolution ultrasound among 2443 participants (1200 women; age, 45 to
    79 years) in the Study of Health in Pomerania (SHIP), a population-based study
    in northeast Germany. RESULTS: In multivariate analysis, serum ferritin levels
    were not independently associated with carotid intima-media thickness among
    women or men. In contrast, the relationship between serum ferritin levels and
    carotid plaque prevalence was significant among men (odds ratio per 1-SD
    increase of serum ferritin levels, 1.33; 95% confidence interval, 1.08 to 1.44)
    yet not among women (odds ratio, 1.29; 95% confidence interval, 0.98 to 1.75).
    However, both men and women showed a dose-response relation between serum
    ferritin levels and carotid atherosclerosis in which higher serum ferritin
    levels were associated with greater odds ratios for carotid plaque prevalence.
    Additionally, there was an interaction of serum ferritin levels with
    low-density lipoprotein (LDL) cholesterol (P=0.039) among men in which the
    association of serum ferritin levels with carotid plaque prevalence became
    stronger with increasing LDL cholesterol levels. CONCLUSIONS: Our study
    identified a relationship between serum ferritin levels and carotid
    atherosclerosis that was potentiated by LDL cholesterol. This relationship adds
    support to the hypothesis of a link between iron and cardiovascular disease.

    PMID: 14726541 [PubMed - as supplied by publisher]

    ————————————————————————–
    ——

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  5. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040117184729.22756.00000178@mb-m18.aol.com…

    > >Subject: Re: iron and cardiovascular disease

    Come on Tom – the world is watching you here – talk about the sick child –
    it’s a straight yes or no – does your science/religion mean the child must
    die ?

  6. admin says:

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/17/2004 5:56 PM Mountain Standard Time
    >Message-id: <buclj2$2c…@newsg2.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040117184729.22756.00000178@mb-m18.aol.com…
    >> >Subject: Re: iron and cardiovascular disease

    >Come on Tom – the world is watching you here – talk about the sick child –
    >it’s a straight yes or no – does your science/religion mean the child must
    >die ?

    You seem to have an inability to read ..

    Did you check the child for vitamin E ..?

    We both know you didn’t ..

    Or you would have answered the question .. quite some time ago ..

    So ..

    Do what you do .. best ..

    Follow the standards of care ..

    Like a good little man ..

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  7. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040118133839.11514.00000220@mb-m12.aol.com…

    - Hide quoted text — Show quoted text -

    > >Subject: Re: iron and cardiovascular disease
    > >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    > >Date: 1/17/2004 5:56 PM Mountain Standard Time
    > >Message-id: <buclj2$2c…@newsg2.svr.pol.co.uk>

    > >"doe" <ironjust…@aol.comdoe> wrote in message
    > >news:20040117184729.22756.00000178@mb-m18.aol.com…
    > >> >Subject: Re: iron and cardiovascular disease

    > >Come on Tom – the world is watching you here – talk about the sick
    child –
    > >it’s a straight yes or no – does your science/religion mean the child
    must
    > >die ?

    > You seem to have an inability to read ..

    > Did you check the child for vitamin E ..?

    > We both know you didn’t ..

    > Or you would have answered the question .. quite some time ago ..

    > So ..

    > Do what you do .. best ..

    > Follow the standards of care ..

    > Like a good little man ..

    So you are openly admitting that you would not follow standards of care.

    As an aside, please tell me in your educated opinion how long a vitamin E
    assay would take to perform, please quote a reference range for a child of
    five years old,  and the specific relevance of such an assay to the
    treatment a child in extremis from severe anaemia.

    MB

  8. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/18/2004 3:20 PM Mountain Standard Time
    >Message-id: <buf0rk$t1…@newsg3.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040118133839.11514.00000220@mb-m12.aol.com…
    >> >Subject: Re: iron and cardiovascular disease
    >> >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >> >Date: 1/17/2004 5:56 PM Mountain Standard Time
    >> >Message-id: <buclj2$2c…@newsg2.svr.pol.co.uk>

    >> >"doe" <ironjust…@aol.comdoe> wrote in message
    >> >news:20040117184729.22756.00000178@mb-m18.aol.com…
    >> >> >Subject: Re: iron and cardiovascular disease

    >> >Come on Tom – the world is watching you here – talk about the sick
    >child –
    >> >it’s a straight yes or no – does your science/religion mean the child
    >must
    >> >die ?

    >> You seem to have an inability to read ..

    >> Did you check the child for vitamin E ..?

    >> We both know you didn’t ..

    >> Or you would have answered the question .. quite some time ago ..

    >> So ..

    >> Do what you do .. best ..

    >> Follow the standards of care ..

    >> Like a good little man ..

    >So you are openly admitting that you would not follow standards of care.

    >As an aside, please tell me in your educated opinion how long a vitamin E
    >assay would take to perform, please quote a reference range for a child of
    >five years old,  and the specific relevance of such an assay to the
    >treatment a child in extremis from severe anaemia.

    No .. I don’t think I will..

    The child suffers from iron overload leading TO his aplastic anemia ..

    Don’t like it .. ?

    Too .. bad ..

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  9. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040118185919.13587.00000139@mb-m24.aol.com…

    > >As an aside, please tell me in your educated opinion how long a vitamin E
    > >assay would take to perform, please quote a reference range for a child
    of
    > >five years old,  and the specific relevance of such an assay to the
    > >treatment a child in extremis from severe anaemia.

    > No .. I don’t think I will..

    Is thatwon’t or can’t ?

    > The child suffers from iron overload leading TO his aplastic anemia ..

    > Don’t like it .. ?

    > Too .. bad ..

    Come on Tom – I’m being serious here.

    OK – so the child might have iron overload. Is that any reason for your
    religion to let him die ?

  10. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/18/2004 5:07 PM Mountain Standard Time
    >Message-id: <buf73t$iu…@newsg4.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040118185919.13587.00000139@mb-m24.aol.com…

    >> >As an aside, please tell me in your educated opinion how long a vitamin E
    >> >assay would take to perform, please quote a reference range for a child
    >of
    >> >five years old,  and the specific relevance of such an assay to the
    >> >treatment a child in extremis from severe anaemia.

    >> No .. I don’t think I will..

    >Is thatwon’t or can’t ?

    Read my lips ..

    When you have 1/100 of the success I am having .. you can make smart remarks ..

    Until then .. STFU ..

    >> The child suffers from iron overload leading TO his aplastic anemia ..

    >> Don’t like it .. ?

    >> Too .. bad ..

    >Come on Tom – I’m being serious here.

    >OK – so the child might have iron overload. Is that any reason for your
    >religion to let him die ?

    Is that any reason for you to give him iron until he . dies .. ?

    You are simply postponing his death with consequences which to some might be
    intolerable ..

    Unless YOU are going to go sit with him in the nut house DUE TO your
    intervention ..

    Of course you wouldn’t get paid then if he did die .. eh ..

    Sort of like the difference between you and Shipman ..

    Which one of you is TRULY his brothers’ keeper ..

    Who loves ya.
    Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  11. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/18/2004 3:20 PM Mountain Standard Time
    >Message-id: <buf0rk$t1…@newsg3.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040118133839.11514.00000220@mb-m12.aol.com…
    >> >Subject: Re: iron and cardiovascular disease
    >> >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >> >Date: 1/17/2004 5:56 PM Mountain Standard Time
    >> >Message-id: <buclj2$2c…@newsg2.svr.pol.co.uk>

    >> >"doe" <ironjust…@aol.comdoe> wrote in message
    >> >news:20040117184729.22756.00000178@mb-m18.aol.com…
    >> >> >Subject: Re: iron and cardiovascular disease

    >> >Come on Tom – the world is watching you here – talk about the sick
    >child –
    >> >it’s a straight yes or no – does your science/religion mean the child
    >must
    >> >die ?

    >> You seem to have an inability to read ..

    >> Did you check the child for vitamin E ..?

    >> We both know you didn’t ..

    >> Or you would have answered the question .. quite some time ago ..

    >> So ..

    >> Do what you do .. best ..

    >> Follow the standards of care ..

    >> Like a good little man ..

    >So you are openly admitting that you would not follow standards of care.

    This link leads to studies of .. NOT .. following ‘standards of care’ ..

    http://tinyurl.com/38×49

    The studies show results of reduction of hospital presentation of 10 x 1 ..

    ONE THOUSAND PERCENT reduction in use of ‘hospital services’ ..

    That would mean 1000 thousand less PERCENT of YOUR .. wage .. out .. the ..
    door ..

    Can’t have that .. eh .. manky ..

    So not surprising the intervention isn’t being implemented ..

    And as an ASIDE ..

    Seems it is closely related to YOUR patient .. eh ..

    Since you didn’t say .. what IS the etiology of the anemia .. wouldn’t be
    sickle or thalassemia would it .. ?

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  12. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: ironjust…@aol.comdoe  (doe)
    >Date: 1/18/2004 11:38 AM Mountain Standard Time
    >Message-id: <20040118133839.11514.00000…@mb-m12.aol.com>

    >>Subject: Re: iron and cardiovascular disease
    >>From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >>Date: 1/17/2004 5:56 PM Mountain Standard Time
    >>Message-id: <buclj2$2c…@newsg2.svr.pol.co.uk>

    >>"doe" <ironjust…@aol.comdoe> wrote in message
    >>news:20040117184729.22756.00000178@mb-m18.aol.com…
    >>> >Subject: Re: iron and cardiovascular disease

    >>Come on Tom – the world is watching you here – talk about the sick child –
    >>it’s a straight yes or no – does your science/religion mean the child must
    >>die ?

    >You seem to have an inability to read ..

    >Did you check the child for vitamin E ..?

    >We both know you didn’t ..

    >Or you would have answered the question .. quite some time ago ..

    >So ..

    Vitamin E Regulation of Mitochondrial Superoxide Generation.

    Chow CK Graduate Center for Nutritional Sciences, and Kentucky Agricultural
    Experiment Station, University of Kentucky, Lexington, Ky., USA.

    Biol Signals Recept 2001 Jan;10(1-2):112-124

    The mitochondrion is the greatest source, as well as the target, of reactive
    oxygen species (ROS). Increasing evidence indicates that vitamin E can act as a
    biological modifier independently of its antioxidant activity. Experimental
    evidence available shows that vitamin E is capable of dose-dependently
    regulating mitochondrial generation of superoxide and hydrogen peroxide.
    Vitamin E may modulate mitochondrial production and levels of superoxide by
    preventing electron leakage, by mediating the superoxide generation systems
    directly and/or by scavenging superoxide generated. By downregulating
    mitochondrial generation of superoxide and related ROS, vitamin E not only
    attenuates oxidative damage but also modulates the expression and activation of
    signal transduction pathways and other redox-sensitive biological modifiers.
    Copyright 2001 S. Karger AG, Basel

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  13. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040118214714.13501.00000180@mb-m24.aol.com…

    > And as an ASIDE ..

    > Seems it is closely related to YOUR patient .. eh ..

    > Since you didn’t say .. what IS the etiology of the anemia .. wouldn’t be
    > sickle or thalassemia would it .. ?

    LOL – didn’t we establish last year that you don’t understand thalassemia !

  14. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040119115233.12638.00000329@mb-m29.aol.com…

    - Hide quoted text — Show quoted text -

    > >Subject: Re: iron and cardiovascular disease
    > >From: ironjust…@aol.comdoe  (doe)
    > >Date: 1/18/2004 11:38 AM Mountain Standard Time
    > >Message-id: <20040118133839.11514.00000…@mb-m12.aol.com>

    > >>Subject: Re: iron and cardiovascular disease
    > >>From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    > >>Date: 1/17/2004 5:56 PM Mountain Standard Time
    > >>Message-id: <buclj2$2c…@newsg2.svr.pol.co.uk>

    > >>"doe" <ironjust…@aol.comdoe> wrote in message
    > >>news:20040117184729.22756.00000178@mb-m18.aol.com…
    > >>> >Subject: Re: iron and cardiovascular disease

    > >>Come on Tom – the world is watching you here – talk about the sick
    child –
    > >>it’s a straight yes or no – does your science/religion mean the child
    must
    > >>die ?

    > >You seem to have an inability to read ..

    > >Did you check the child for vitamin E ..?

    > >We both know you didn’t ..

    > >Or you would have answered the question .. quite some time ago ..

    > >So ..

    > Vitamin E Regulation of Mitochondrial Superoxide Generation.

    > Chow CK Graduate Center for Nutritional Sciences, and Kentucky
    Agricultural
    > Experiment Station, University of Kentucky, Lexington, Ky., USA.

    > Biol Signals Recept 2001 Jan;10(1-2):112-124

    > The mitochondrion is the greatest source, as well as the target, of
    reactive
    > oxygen species (ROS). Increasing evidence indicates that vitamin E can act
    as a
    > biological modifier independently of its antioxidant activity.
    Experimental
    > evidence available shows that vitamin E is capable of dose-dependently
    > regulating mitochondrial generation of superoxide and hydrogen peroxide.
    > Vitamin E may modulate mitochondrial production and levels of superoxide
    by
    > preventing electron leakage, by mediating the superoxide generation
    systems
    > directly and/or by scavenging superoxide generated. By downregulating
    > mitochondrial generation of superoxide and related ROS, vitamin E not only
    > attenuates oxidative damage but also modulates the expression and
    activation of
    > signal transduction pathways and other redox-sensitive biological
    modifiers.
    > Copyright 2001 S. Karger AG, Basel

    ???

    I think the phrase "irrelevant" springs to mind

  15. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040118192744.13587.00000141@mb-m24.aol.com…

    - Hide quoted text — Show quoted text -

    > >Subject: Re: iron and cardiovascular disease
    > >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    > >Date: 1/18/2004 5:07 PM Mountain Standard Time
    > >Message-id: <buf73t$iu…@newsg4.svr.pol.co.uk>

    > >"doe" <ironjust…@aol.comdoe> wrote in message
    > >news:20040118185919.13587.00000139@mb-m24.aol.com…

    > >> >As an aside, please tell me in your educated opinion how long a
    vitamin E
    > >> >assay would take to perform, please quote a reference range for a
    child
    > >of
    > >> >five years old,  and the specific relevance of such an assay to the
    > >> >treatment a child in extremis from severe anaemia.

    > >> No .. I don’t think I will..

    > >Is thatwon’t or can’t ?

    > Read my lips ..

    > When you have 1/100 of the success I am having .. you can make smart
    remarks ..

    > Until then .. STFU ..

    Getting a bit stressy now ?

    - Hide quoted text — Show quoted text -

    > >> The child suffers from iron overload leading TO his aplastic anemia ..

    > >> Don’t like it .. ?

    > >> Too .. bad ..

    > >Come on Tom – I’m being serious here.

    > >OK – so the child might have iron overload. Is that any reason for your
    > >religion to let him die ?

    > Is that any reason for you to give him iron until he . dies .. ?

    > You are simply postponing his death with consequences which to some might
    be
    > intolerable ..

    > Unless YOU are going to go sit with him in the nut house DUE TO your
    > intervention ..

    > Of course you wouldn’t get paid then if he did die .. eh ..

    > Sort of like the difference between you and Shipman ..

    > Which one of you is TRULY his brothers’ keeper ..

    "You are simply postponing his death" – so the voices in your head WILL let
    the child die then ?

  16. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/19/2004 1:08 PM Mountain Standard Time
    >Message-id: <buhdfk$5o…@news7.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040118192744.13587.00000141@mb-m24.aol.com…
    >> >Subject: Re: iron and cardiovascular disease
    >> >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >> >Date: 1/18/2004 5:07 PM Mountain Standard Time
    >> >Message-id: <buf73t$iu…@newsg4.svr.pol.co.uk>

    >> >"doe" <ironjust…@aol.comdoe> wrote in message
    >> >news:20040118185919.13587.00000139@mb-m24.aol.com…

    >> >> >As an aside, please tell me in your educated opinion how long a
    >vitamin E
    >> >> >assay would take to perform, please quote a reference range for a
    >child
    >> >of
    >> >> >five years old,  and the specific relevance of such an assay to the
    >> >> >treatment a child in extremis from severe anaemia.

    >> >> No .. I don’t think I will..

    >> >Is thatwon’t or can’t ?

    >> Read my lips ..

    >> When you have 1/100 of the success I am having .. you can make smart
    >remarks ..

    >> Until then .. STFU ..

    >Getting a bit stressy now ?

    >> >> The child suffers from iron overload leading TO his aplastic anemia ..

    >> >> Don’t like it .. ?

    >> >> Too .. bad ..

    >> >Come on Tom – I’m being serious here.

    >> >OK – so the child might have iron overload. Is that any reason for your
    >> >religion to let him die ?

    >> Is that any reason for you to give him iron until he . dies .. ?

    >> You are simply postponing his death with consequences which to some might
    >be
    >> intolerable ..

    >> Unless YOU are going to go sit with him in the nut house DUE TO your
    >> intervention ..

    >> Of course you wouldn’t get paid then if he did die .. eh ..

    >> Sort of like the difference between you and Shipman ..

    >> Which one of you is TRULY his brothers’ keeper ..

    >"You are simply postponing his death" – so the voices in your head WILL let
    >the child die then ?

    Die .. ?

    Who loves ya.
    Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  17. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/19/2004 1:07 PM Mountain Standard Time
    >Message-id: <buhdd6$g7…@newsg3.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040119115233.12638.00000329@mb-m29.aol.com…
    >> >Subject: Re: iron and cardiovascular disease
    >> >From: ironjust…@aol.comdoe  (doe)
    >> >Date: 1/18/2004 11:38 AM Mountain Standard Time
    >> >Message-id: <20040118133839.11514.00000…@mb-m12.aol.com>

    >> >>Subject: Re: iron and cardiovascular disease
    >> >>From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >> >>Date: 1/17/2004 5:56 PM Mountain Standard Time
    >> >>Message-id: <buclj2$2c…@newsg2.svr.pol.co.uk>

    >> >>"doe" <ironjust…@aol.comdoe> wrote in message
    >> >>news:20040117184729.22756.00000178@mb-m18.aol.com…
    >> >>> >Subject: Re: iron and cardiovascular disease

    >> >>Come on Tom – the world is watching you here – talk about the sick
    >child –
    >> >>it’s a straight yes or no – does your science/religion mean the child
    >must
    >> >>die ?

    >> >You seem to have an inability to read ..

    >> >Did you check the child for vitamin E ..?

    >> >We both know you didn’t ..

    >> >Or you would have answered the question .. quite some time ago ..

    >> >So ..

    >> Vitamin E Regulation of Mitochondrial Superoxide Generation.

    >> Chow CK Graduate Center for Nutritional Sciences, and Kentucky
    >Agricultural
    >> Experiment Station, University of Kentucky, Lexington, Ky., USA.

    >> Biol Signals Recept 2001 Jan;10(1-2):112-124

    >> The mitochondrion is the greatest source, as well as the target, of
    >reactive
    >> oxygen species (ROS). Increasing evidence indicates that vitamin E can act
    >as a
    >> biological modifier independently of its antioxidant activity.
    >Experimental
    >> evidence available shows that vitamin E is capable of dose-dependently
    >> regulating mitochondrial generation of superoxide and hydrogen peroxide.
    >> Vitamin E may modulate mitochondrial production and levels of superoxide
    >by
    >> preventing electron leakage, by mediating the superoxide generation
    >systems
    >> directly and/or by scavenging superoxide generated. By downregulating
    >> mitochondrial generation of superoxide and related ROS, vitamin E not only
    >> attenuates oxidative damage but also modulates the expression and
    >activation of
    >> signal transduction pathways and other redox-sensitive biological
    >modifiers.
    >> Copyright 2001 S. Karger AG, Basel

    >???

    >I think the phrase "irrelevant" springs to mind

    I suppose since it is reference to Fanconi .. it would be .. to .. you ..

    Who loves ya.
    Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  18. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040119161257.11625.00000262@mb-m12.aol.com…

    > >I think the phrase "irrelevant" springs to mind

    > I suppose since it is reference to Fanconi .. it would be .. to .. you ..

    > Who loves ya.
    > Tom

    I’ve wasted an hour looking round the newsgroups tonight Tom.

    As it would seem that I’m the onl;y person who ever replies to you, don’t
    you think that a little more in the manners department might help.

    Or you won’t have any friends at all….

    MB

  19. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/19/2004 3:35 PM Mountain Standard Time
    >Message-id: <buhm39$cq…@news7.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040119161257.11625.00000262@mb-m12.aol.com…

    >> >I think the phrase "irrelevant" springs to mind

    >> I suppose since it is reference to Fanconi .. it would be .. to .. you ..

    >> Who loves ya.
    >> Tom

    >I’ve wasted an hour looking round the newsgroups tonight Tom.

    http://tinyurl.com/2zgb9

    >As it would seem that I’m the onl;y person who ever replies to you, don’t
    >you think that a little more in the manners department might help.

    Manners ..?

    >Or you won’t have any friends at all….

    Friends .. ? friends ? I need no stinking friends ..

    Who loves ya.
    Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  20. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20040120174943.24726.00000348@mb-m16.aol.com…

    - Hide quoted text — Show quoted text -

    > >Subject: Re: iron and cardiovascular disease
    > >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    > >Date: 1/19/2004 3:35 PM Mountain Standard Time
    > >Message-id: <buhm39$cq…@news7.svr.pol.co.uk>

    > >"doe" <ironjust…@aol.comdoe> wrote in message
    > >news:20040119161257.11625.00000262@mb-m12.aol.com…

    > >> >I think the phrase "irrelevant" springs to mind

    > >> I suppose since it is reference to Fanconi .. it would be .. to .. you
    ..

    > >> Who loves ya.
    > >> Tom

    > >I’ve wasted an hour looking round the newsgroups tonight Tom.

    > http://tinyurl.com/2zgb9

    So what ?

    > >As it would seem that I’m the onl;y person who ever replies to you, don’t
    > >you think that a little more in the manners department might help.

    > Manners ..?

    > >Or you won’t have any friends at all….

    > Friends .. ? friends ? I need no stinking friends ..

    Seriously Tom – YOU NEED FRIENDS.

    Your crackpot religion is no substitute for meeting & talking and
    associating with real people.

  21. admin says:

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/20/2004 4:28 PM Mountain Standard Time
    >Message-id: <bukdit$65…@newsg4.svr.pol.co.uk>

    >Your crackpot religion is no substitute for meeting & talking and
    >associating with real people.

    Is this some sort of religious newsgroup?

    So keep your opinions to yourself ..

    Dig ..?

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  22. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >Date: 1/20/2004 4:28 PM Mountain Standard Time
    >Message-id: <bukdit$65…@newsg4.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20040120174943.24726.00000348@mb-m16.aol.com…
    >> >Subject: Re: iron and cardiovascular disease
    >> >From: "Manky Badger" m…@idontwantspamdotpuritancotfreeserve.co.uk
    >> >Date: 1/19/2004 3:35 PM Mountain Standard Time
    >> >Message-id: <buhm39$cq…@news7.svr.pol.co.uk>

    >> >"doe" <ironjust…@aol.comdoe> wrote in message
    >> >news:20040119161257.11625.00000262@mb-m12.aol.com…

    >> >> >I think the phrase "irrelevant" springs to mind

    >> >> I suppose since it is reference to Fanconi .. it would be .. to .. you
    >..

    >> >> Who loves ya.
    >> >> Tom

    >> >I’ve wasted an hour looking round the newsgroups tonight Tom.

    >> http://tinyurl.com/2zgb9

    >So what ?

    Listen .. to .. what .. I .. am .. saying ..

    Iron is in abundance from birth ..

    Too much iron leads to a decrease in vitamin E in the body.

    Vitamin E is essential for the proper production of red blood cells ..

    Too much iron is a cause of decreased antioxidant capacity in the body ..

    A chelatable iron pool exists in the cytosol of the aplastic cell ..

    This chelatable iron pool must be dealt with and this decrease in antioxidants
    must be dealt with.

    This means in the perfect world the iron would be immediately decreased and the
    antioxidant capacity immediately increased.

    This is accomplished most effectively by blood removal / iron reduction
    therapy.

    Biochem Pharmacol 1999 Jun 15;57(12):1345-9 Therapy by taking away: the case of
    iron.

    Polla BS Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal, Paris,
    France. Barbara.Po…@cochin.univ-paris5.fr

    The recent finding of the beneficial effects of iron deprivation in the outcome
    of muscle necrosis in an animal model of genetic myopathy served as the basis
    of this commentary.

    Here, "taking away" iron by controlled dietary deprivation is proposed as a
    reasonable, feasible, cheap, and efficient clinical approach to many diverse
    diseases, all of which have a free radical component.

    Indeed, iron potentiates the generation of the highly reactive and toxic
    hydroxyl radical, and, thus, of oxidative damage.

    Iron deprivation may represent the first really efficient antioxidant,
    preventing oxidative stress in all subcellular compartments, tissues, and
    organs.

    Iron/iron deprivation also modulates programmed cell death (apoptosis), which
    should be the subject of further studies to better define the mechanisms
    mediating these complex effects.

    Finally, related to its antioxidant effects, iron deprivation may find
    applications in the anti-aging field, whether programmed or premature aging,
    and whether in cosmetics or in gerontology.

    Publication Types: * Review * Review, tutorial PMID: 10353254, UI: 99279694

    _________________________________________________________________
    _________________________________________________________________

    CONCLUSION
    In conclusion, therapy by taking away (iron) has a great potential for many
    different diseases, all of which share ROS-mediated mechanisms.

    The development of new, non-toxic , easily administrable iron chelators such as
    IRCO11 may shortly become the most efficient and fashionable antioxidant,
    anti-aging, anti-infectious, and anti-inflammatroy therapy.

    In the meantime, although taking away by controlled dietary deprivation is less
    attractive , it should be considered in all of the above, as well as in the
    currently incurable, devastating genetic or acquired myopathies such as DMD.

    You .. figure .. it .. out ..

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  23. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >>> http://tinyurl.com/2zgb9

    >>So what ?

    >Listen .. to .. what .. I .. am .. saying ..

    >Iron is in abundance from birth ..

    >Too much iron leads to a decrease in vitamin E in the body.

    >Vitamin E is essential for the proper production of red blood cells ..

    >Too much iron is a cause of decreased antioxidant capacity in the body ..

    >A chelatable iron pool exists in the cytosol of the aplastic cell ..

    >This chelatable iron pool must be dealt with and this decrease in
    >antioxidants
    >must be dealt with.

    >This means in the perfect world the iron would be immediately decreased and
    >the
    >antioxidant capacity immediately increased.

    >This is accomplished most effectively by blood removal / iron reduction
    >therapy.

    >Biochem Pharmacol 1999 Jun 15;57(12):1345-9 Therapy by taking away: the case
    >of
    >iron.

    >Polla BS Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal,
    >Paris,
    >France. Barbara.Po…@cochin.univ-paris5.fr

    >The recent finding of the beneficial effects of iron deprivation in the
    >outcome
    >of muscle necrosis in an animal model of genetic myopathy served as the basis
    >of this commentary.

    >Here, "taking away" iron by controlled dietary deprivation is proposed as a
    >reasonable, feasible, cheap, and efficient clinical approach to many diverse
    >diseases, all of which have a free radical component.

    >Indeed, iron potentiates the generation of the highly reactive and toxic
    >hydroxyl radical, and, thus, of oxidative damage.

    >Iron deprivation may represent the first really efficient antioxidant,
    >preventing oxidative stress in all subcellular compartments, tissues, and
    >organs.

    >Iron/iron deprivation also modulates programmed cell death (apoptosis), which
    >should be the subject of further studies to better define the mechanisms
    >mediating these complex effects.

    >Finally, related to its antioxidant effects, iron deprivation may find
    >applications in the anti-aging field, whether programmed or premature aging,
    >and whether in cosmetics or in gerontology.

    >Publication Types: * Review * Review, tutorial PMID: 10353254, UI: 99279694

    >_________________________________________________________________
    >_________________________________________________________________

    >CONCLUSION
    >In conclusion, therapy by taking away (iron) has a great potential for many
    >different diseases, all of which share ROS-mediated mechanisms.

    >The development of new, non-toxic , easily administrable iron chelators such
    >as
    >IRCO11 may shortly become the most efficient and fashionable antioxidant,
    >anti-aging, anti-infectious, and anti-inflammatroy therapy.

    >In the meantime, although taking away by controlled dietary deprivation is
    >less
    >attractive , it should be considered in all of the above, as well as in the
    >currently incurable, devastating genetic or acquired myopathies such as DMD.

    >You .. figure .. it .. out ..

     J Leukoc Biol. 1992 Sep; 52(3): 357-62.  Related Articles, Links  

    Release of active oxygen radicals by leukocytes of Fanconi anemia patients.

    Korkina LG, Samochatova EV, Maschan AA, Suslova TB, Cheremisina ZP, Afanas’ev
    IB.

    Russian Institute of Hematology for Children, Moscow.

    The release of oxygen radicals by blood and bone marrow leukocytes of patients
    with Fanconi anemia (FA) has been studied. It was found that the nonstimulated
    FA leukocytes and those stimulated by concanavalin A, SiO2, latex, and
    opsonized zymosan produced enhanced levels of luminol- and lucigenin-dependent
    chemiluminescence (CL) in comparison with normal leukocytes. At the same time,
    the ratio of the intensity of lucigenin-dependent CL to that of
    luminol-dependent CL was significantly smaller for FA leukocytes than for
    normal leukocytes. From these findings and from the effects of antioxidative
    enzymes and free radical scavengers on CL, it was concluded that FA leukocytes
    release enhanced amounts of oxygen radicals and that these free radicals
    contain enhanced amounts of hydroxyl or hydroxyl-like radicals more active than
    superoxide ion. It was proposed that elevated reactivity of the oxygen radicals
    released by FA leukocytes may be a major factor in the development of Fanconi
    anemia; this proposal is supported by the first positive results of treatment
    of FA patients with rutin (a nontoxic natural free radical scavenger and
    chelator).

    PMID: 1326022 [PubMed - indexed for MEDLINE]

    ————————————————————————–
    ——

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  24. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: iron and cardiovascular disease
    >From: ironjust…@aol.comdoe  (doe)
    >Date: 1/20/2004 8:51 PM Mountain Standard Time
    >Message-id: <20040120225121.23011.00000…@mb-m04.aol.com>

    >>Subject: Re: iron and cardiovascular disease

    >>>> http://tinyurl.com/2zgb9

    >>>So what ?

    >>Listen .. to .. what .. I .. am .. saying ..

    >>Iron is in abundance from birth ..

    >>Too much iron leads to a decrease in vitamin E in the body.

    >>Vitamin E is essential for the proper production of red blood cells ..

    >>Too much iron is a cause of decreased antioxidant capacity in the body ..

    >>A chelatable iron pool exists in the cytosol of the aplastic cell ..

    >>This chelatable iron pool must be dealt with and this decrease in
    >>antioxidants
    >>must be dealt with.

    >>This means in the perfect world the iron would be immediately decreased and
    >>the
    >>antioxidant capacity immediately increased.

    >>This is accomplished most effectively by blood removal / iron reduction
    >>therapy.

    >>Biochem Pharmacol 1999 Jun 15;57(12):1345-9 Therapy by taking away: the case
    >>of
    >>iron.

    >>Polla BS Laboratoire de Physiologie Respiratoire, UFR Cochin Port-Royal,
    >>Paris,
    >>France. Barbara.Po…@cochin.univ-paris5.fr

    >>The recent finding of the beneficial effects of iron deprivation in the
    >>outcome
    >>of muscle necrosis in an animal model of genetic myopathy served as the
    >basis
    >>of this commentary.

    >>Here, "taking away" iron by controlled dietary deprivation is proposed as a
    >>reasonable, feasible, cheap, and efficient clinical approach to many diverse
    >>diseases, all of which have a free radical component.

    >>Indeed, iron potentiates the generation of the highly reactive and toxic
    >>hydroxyl radical, and, thus, of oxidative damage.

    >>Iron deprivation may represent the first really efficient antioxidant,
    >>preventing oxidative stress in all subcellular compartments, tissues, and
    >>organs.

    >>Iron/iron deprivation also modulates programmed cell death (apoptosis),
    >which
    >>should be the subject of further studies to better define the mechanisms
    >>mediating these complex effects.

    >>Finally, related to its antioxidant effects, iron deprivation may find
    >>applications in the anti-aging field, whether programmed or premature aging,
    >>and whether in cosmetics or in gerontology.

    >>Publication Types: * Review * Review, tutorial PMID: 10353254, UI: 99279694

    >>_________________________________________________________________
    >>_________________________________________________________________

    >>CONCLUSION
    >>In conclusion, therapy by taking away (iron) has a great potential for many
    >>different diseases, all of which share ROS-mediated mechanisms.

    >>The development of new, non-toxic , easily administrable iron chelators such
    >>as
    >>IRCO11 may shortly become the most efficient and fashionable antioxidant,
    >>anti-aging, anti-infectious, and anti-inflammatroy therapy.

    >>In the meantime, although taking away by controlled dietary deprivation is
    >>less
    >>attractive , it should be considered in all of the above, as well as in the
    >>currently incurable, devastating genetic or acquired myopathies such as DMD.

    >>You .. figure .. it .. out ..

    > J Leukoc Biol. 1992 Sep; 52(3): 357-62.  Related Articles, Links  

    >Release of active oxygen radicals by leukocytes of Fanconi anemia patients.

    >Korkina LG, Samochatova EV, Maschan AA, Suslova TB, Cheremisina ZP, Afanas’ev
    >IB.

    >Russian Institute of Hematology for Children, Moscow.

    >The release of oxygen radicals by blood and bone marrow leukocytes of
    >patients
    >with Fanconi anemia (FA) has been studied. It was found that the
    >nonstimulated
    >FA leukocytes and those stimulated by concanavalin A, SiO2, latex, and
    >opsonized zymosan produced enhanced levels of luminol- and
    >lucigenin-dependent
    >chemiluminescence (CL) in comparison with normal leukocytes. At the same
    >time,
    >the ratio of the intensity of lucigenin-dependent CL to that of
    >luminol-dependent CL was significantly smaller for FA leukocytes than for
    >normal leukocytes. From these findings and from the effects of antioxidative
    >enzymes and free radical scavengers on CL, it was concluded that FA
    >leukocytes
    >release enhanced amounts of oxygen radicals and that these free radicals
    >contain enhanced amounts of hydroxyl or hydroxyl-like radicals more active
    >than
    >superoxide ion. It was proposed that elevated reactivity of the oxygen
    >radicals
    >released by FA leukocytes may be a major factor in the development of Fanconi
    >anemia; this proposal is supported by the first positive results of treatment
    >of FA patients with rutin (a nontoxic natural free radical scavenger and
    >chelator).

    >PMID: 1326022 [PubMed - indexed for MEDLINE]

    >————————————————————————–
    >——

    Ter Arkh. 1989; 61(7): 32-6.  Related Articles, Links  

    [The role of free oxygen radicals in the pathogenesis of Fanconi's anemia]

    [Article in Russian]

    Rumiantsev AG, Samochatova EV, Afanas’ev IB, Korkina LG, Suslova TB.

    The authors describe the results of a study into antioxidants (superoxide
    dismutase and catalase) and production of the active forms of oxygen
    (superoxide anion radical, hydrogen peroxide, hydroxyl radical, and singlet
    oxygen) by blood and bone marrow leukocytes from patients with Fanconi’s
    anemia. The generation of the active forms of oxygen was induced by silica
    particles while the formation of radical products was recorded by means of
    luminol-dependent chemiluminescence. Unbalanced excessive production of oxygen
    radicals such as hydroxyl radicals combined with a decrease in the activity of
    antioxidant defence enzymes was discovered. It is believed that it is this
    circumstance that causes the derangement of the membranous structures and
    multiple breakdowns in the hereditary apparatus. It is suggested that
    antiradical preparations may be applied to correcting therapy of patients with
    Fanconi’s anemia.

    Publication Types:
    Case Reports

    PMID: 2588140 [PubMed - indexed for MEDLINE]

    ————————————————————————–
    ——

    Who loves ya.
    Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking