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Oxidative stress-induced DNA damage.

 Ann N Y Acad Sci. 2004 Jun;1019:285-8.  Related Articles, Links  

Lysosomal redox-active iron is important for oxidative stress-induced DNA

Kurz T, Leake A, von Zglinicki T, Brunk UT.

School of Clinical Medical Sciences-Gerontology, University of Newcastle upon
Tyne, Newcastle General Hospital, Henry Wellcome Laboratory for Biogerontology
Research, NE4 6BE, United Kingdom. tino.k…

Data show that specifically chelating lysosomal redox-active iron can prevent
most H(2)O(2)-induced DNA damage. Lysosomes seem to contain the major pool of
redox-active labile iron within the cell. Under oxidative stress conditions,
this iron may then relocate to the nucleus and play an important role for DNA
damage by taking part in Fenton reactions.

PMID: 15247030 [PubMed - indexed for MEDLINE]


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