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Oxidative stress / meat consumption

dietary heme iron was positively related to serum GGT leve

Free Radic Res. 2004 Jun;38(6):535-9.  Related Articles, Links  

Is serum gamma glutamyltransferase a marker of oxidative stress?

Lee DH, Blomhoff R, Jacobs DR Jr.

Department of Preventive Medicine and Health Promotion Research Center, School
of Medicine, Kyungpook National University, Daegu, South Korea.

The primary role of cellular gamma glutamyltransferase (GGT) is to metabolize
extracellular reduced glutathione (GSH), allowing for precursor amino acids to
be assimilated and reutilized for intracellular GSH synthesis. Paradoxically,
recent experimental studies indicate that cellular GGT may also be involved in
the generation of reactive oxygen species in the presence of iron or other
transition metals. Although the relationship between cellular GGT and serum GGT
is not known and serum GGT activity has been commonly used as a marker for
excessive alcohol consumption or liver diseases, our series of epidemiological
studies consistently suggest that serum GGT within its normal range might be an
early and sensitive enzyme related to oxidative stress. For example, serum and
dietary antioxidant vitamins had inverse, dose-response relations to serum GGT
level within its normal range, whereas dietary heme iron was positively related
to serum GGT level. More importantly, serum GGT level within its normal range
positively predicted F2-isoprostanes, an oxidative damage product of
arachidonic acid, and fibrinogen and C-reactive protein, markers of
inflammation, which were measured 5 or 15 years later, in dose-response
manners. These findings suggest that strong associations of serum GGT with many
cardiovascular risk factors and/or events might be explained by a mechanism
related to oxidative stress. Even though studies on serum and/or cellular GGT
is at a beginning stage, our epidemiological findings suggest that serum GGT
might be useful in studying oxidative stress-related issues in both
epidemiological and clinical settings.

PMID: 15346644 [PubMed - in process]


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