Pathology and laboratory medicine

pathology, laboratory medicine, clinical pathology laboratories, pathology definition, clinical pathology, pathology laboratory, pathology report, human pathology, lab medicine

Iron / acid / alkaline / dialysis

Nephrol Dial Transplant. 2004 Aug 3 [Epub ahead of print] Related Articles,
Links  

Oxidative stress induced by iron released from transferrin in low pH peritoneal
dialysis solution.

Yamaji Y, Nakazato Y, Oshima N, Hayashi M, Saruta T.

Kidney Disease Center and Internal Medicine, Saitama Social Insurance Hospital,
Saitama-City, Saitama, Japan.

BACKGROUND: Transferrin binds extracellular iron and protects tissues from
iron-induced oxidative stress. The binding of iron and transferrin is pH
dependent and conventional peritoneal dialysis (PD) solutions have
unphysiologically low pH values. Herein, we investigated whether conventional
PD solution releases iron from transferrin and if the released iron causes
oxidative stress. METHODS: Effects of PD solutions on iron binding to
transferrin were examined with purified human transferrin and transferrin in
dialysates drained from PD patients. Oxidative stress induced by iron released
from transferrin was evaluated in terms of the formation of thiobarbituric acid
reactive substance (TBARS) and protein carbonylation in the human red blood
cell (RBC) membrane. The iron deposition in peritoneal tissue from PD patients
was evaluated by Perls’ staining with diaminobenzidine intensification.
RESULTS: Low pH PD solution released iron from transferrin. This iron release
occurred within 1 min. Iron release was not observed in neutralized PD
solution. Iron released from transferrin in low pH PD solution increased TBARS
formation and protein carbonylation in the human RBC membrane. Iron deposition,
which is prominent in the fibrotic area facing the peritoneal cavity, was
observed in the peritoneum of PD patients. CONCLUSIONS: Iron released from
transferrin in low pH PD solution can produce oxidative stress in the
peritoneum of a PD patient. Neutralizing PD solution can avoid this problem.
Iron deposition in the peritoneum may participate in the pathogenesis of
peritoneal fibrosis in PD patients.

PMID: 15292463 [PubMed - as supplied by publisher]

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——

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cbd oil reviews and complaints .
Comments (6)

When Pseudos Play SEE-SAW

<
<
http://www.edconrad.com/ebay/coalbones/inslate5.jpg
http://www.edconrad.com/ebay/coalbones/inslate_mysterious.jpg
<
==================================

No? Well, here’s a few more you can say you didn’t saw…

==================================
<

- — -

>   PETRIFIED BONES, TEETH AND SOFT ORGANS
>   DISCOVERED BETWEEN ANTHRACITE VEINS
<
> http://www.edconrad.com/ebay/Smith/z11calv.jpg
> http://www.edconrad.com/ebay/Petrified/z8femur.jpg
> http://www.edconrad.com/ebay/Petrified/z5gall.jpg
> http://www.edconrad.com/ebay/Petrified/newtibia.jpg
> http://www.edconrad.com/ebay/Petrified/skullb.jpg
> http://www.edconrad.com/ebay/Petrified/z9lung.jpg
> http://www.edconrad.com/ebay/brain/MVC-001S.JPG
> http://www.edconrad.com/ebay/Newpix5/MVC-002S.JPG
> http://www.edconrad.com/ebay/Bones/MVC-006S.JPG
> http://www.edconrad.com/ebay/Petrified/1tooth.jpg
> http://www.edconrad.com/ebay/Newpix3/z3dino.jpg
> http://www.edconrad.com/ebay/Petrified/MVC-013F.JPG
> http://www.edconrad.com/ebay/Petrified/MVC-012F.JPG
> http://www.edconrad.com/ebay/Day/MVC-005S.JPG
> http://www.edconrad.com/ebay/Scorpion/MVC-001S.JPG
> http://www.edconrad.com/ebay/Scorpion/MVC-010S.JPG
> http://www.edconrad.com/ebay/Scorpion/MVC-020S.JPG
> http://www.edconrad.com/ebay/SCORPIONS/MVC-039S.JPG
> http://www.edconrad.com/ebay/Tool/MVC-003S.JPG
> http://www.edconrad.com/ebay/Tool/MVC-005S.JPG
> http://www.edconrad.com/ebay/FINGER/MVC-008S.JPG
> http://www.edconrad.com/ebay/FINGER/MVC-011S.JPG

<
Petrified human toe (with toe nail).
> http://www.edconrad.com/ebay/Au29/MVC-017S.JPG

<
Petrified human finger (with finger nail)
AND petrified human toe (with toe nail):
> http://www.edconrad.com/ebay/Au29/MVC-016S.JPG

<
<

> \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\//////////////////////////// /////////////////

http://www.edconrad.com/oldascoal/images/quotesnew.gif
   and
> http://edconrad.com/canals/hooton.gif

<
Ed Conrad
> http://www.edconrad.com

   Man as Old as Coal

- — -

> \\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\\//////////////////////////// //////////////////

No Comments

Man-made Handle Found in Coal Seams

- — -

>> <
>> There has been some debate about the oldest
>> man-made tool.

>> The oldest man-made tolld dates back 280,000,000 years
>>  – give or take a few centuries.
>> <
>> I’is the handcarved piece of wood carved — into a handle
>>  for a weapon or a tool (possibly both).
>> <
>> It was manufactured during the Carboniferous Period
>> — you know, while coal was being formed — and, in fact,
>> it’s SO old that the wood has turned to coal.
>> <
>> Heck, I’ll even prove it with pictures.
>> <
>>  http://www.edconrad.com/ebay/Tool/MVC-001S.JPG
>>  http://www.edconrad.com/ebay/Tool/MVC-003S.JPG
>>>http://www.edconrad.com/ebay/Tool/MVC-005S.JPG

<
Now, another strange artifact…

>Could be a stick! Could be a snake!….

> http://www.edconrad.com/ebay/pp/MVC-020S.JPG
> http://www.edconrad.com/ebay/pp/MVC-021S.JPG
> http://www.edconrad.com/ebay/pp/MVC-022S.JPG

Might well be man’s oldest, most workable "tool"
(also found between anthracite veins.)
<
Ed Conrad
> http://www.edconrad.com

<
=========================================

- — -

Ed Conrad
>  http://www.edconrad.com
>  Man as Old as Coal (maybe a great deal older)
..
>=========================================

>>    DISCOVERIES IN CARBONIFEROUS STRATA
>>        (Time to Burn the Anthropology Textbooks)

>> http://www.edconrad.com/ebay/Smith/z11calv.jpg
>> http://www.edconrad.com/ebay/Petrified/z8femur.jpg
>> http://www.edconrad.com/ebay/Petrified/z5gall.jpg
>> http://www.edconrad.com/ebay/Petrified/newtibia.jpg
>> http://www.edconrad.com/ebay/Petrified/skullb.jpg

>> http://www.edconrad.com/ebay/Petrified/z9lung.jpg
>> http://www.edconrad.com/ebay/brain/MVC-001S.JPG
>> http://www.edconrad.com/ebay/Newpix5/MVC-002S.JPG
>> http://www.edconrad.com/ebay/Bones/MVC-006S.JPG
>> http://www.edconrad.com/ebay/Petrified/1tooth.jpg

>> http://www.edconrad.com/ebay/Tool/MVC-003S.JPG
>> http://www.edconrad.com/ebay/Tool/MVC-005S.JPG
>> http://www.edconrad.com/ebay/Newpix3/z3dino.jpg
>> http://www.edconrad.com/ebay/Petrified/MVC-013F.JPG
>> http://www.edconrad.com/ebay/Petrified/MVC-012F.JPG

>> http://www.edconrad.com/ebay/Day/MVC-005S.JPG
>> http://www.edconrad.com/ebay/Scorpion/MVC-001S.JPG
>> http://www.edconrad.com/ebay/Scorpion/MVC-010S.JPG
>> http://www.edconrad.com/ebay/Scorpion/MVC-020S.JPG
> > http://www.edconrad.com/ebay/Tool/MVC-003S.JPG
>> http://www.edconrad.com/ebay/Tool/MVC-005S.JPG

>============================================

>> Here’s a piece of petrified bone still embedded in slate.

> http://www.edconrad.com/ebay/S1/MVC-019S.JPG
> http://www.edconrad.com/ebay/S1/MVC-018S.JPG
> http://www.edconrad.com/ebay/S1/MVC-020S.JPG
> http://www.edconrad.com/ebay/S1/MVC-021S.JPG

>>Petrified claw:
>> http://www.edconrad.com/ebay/KeySpecimen\MVC-011S.JPG

No Comments

Liver transplantation / iron

<<snip>>
The graft hepatic iron concentration may be one of the factors involved in
early fibrosis progression
<<snip>>

J Hepatol. 2004 Aug;41(2):307-11.  Links

Evaluation of donor hepatic iron concentration as a factor of early fibrotic
progression after liver transplantation.

Toniutto P, Fabris C, Bortolotti N, Minisini R, Avellini C, Fumo E, Pirisi M.

Liver Transplantation Unit, DPMSC, University of Udine, Udine, Italy.

BACKGROUND/AIMS: Hepatic iron may act as an important co-morbid factor in
non-hemochromatotic liver diseases, but whether it may favour fibrogenesis
after liver transplantation is not known. To verify whether the hepatic iron
concentration of the graft might play a role in the rapid fibrotic progression
frequently observed after liver transplantation for chronic hepatitis C.
METHODS: The hepatic iron concentration, measured at the time of the donor
operation, was retrospectively related to the histological follow-up data of 68
recipients (49 males, 19 females), of whom 38 were hepatitis C virus positive.
RESULTS: The hepatic iron concentration in donor liver biopsies ranged from 25
to 7100 microg/gdw. After a median follow-up of 19 months, nine patients (five
HCV positive) had a staging score >3. There was a significant association
between a higher frequency of increasing staging and donor age >50 years. In
female HCV-positive recipients, a graft hepatic iron concentration >1200
microg/gdw was associated with fibrosis progression >0.15 fibrosis units per
month (4/4 vs. 1/7, p<0.01). CONCLUSIONS: The graft hepatic iron concentration
may be one of the factors involved in early fibrosis progression due to
recurrent hepatitis C in female recipients.

PMID: 15288481 [PubMed - in process]

————————————————————————–
——

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

No Comments

Oxidative stress theory of Aids

http://tinyurl.com/ypzjw

http://tinyurl.com/2m6hg

<<snip>>
A possible detrimental role of iron in HIV infection would have serious public
health implications.
<<snip>>

PMID: 12792358 [PubMed - indexed for MEDLINE]

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

No Comments

Bladder perforation treatment

Hello all, well this may sound unusual but I am having intermittent
catheterisations due to a problem in the bladder, and up to day I was not
trying to use the bladder during the procedure. However I thought to use the
bladder a bit at the end just to make sure the bladder got empty, but
suddenly some "clean"urine started flowing at the beginning, but then it
turned to more and more to dark red and was running along with urine and
then I got a bit panicked and removed the catheter. I do not feel any pain
now, however I am fearing it is possible I perforated the bladder!!!

My question is, does this kind of bladder perforations heal by themselves? I
am using catheter size 12 with xylocaine gel.

Thanks in advance!

Comments (4)

solapur medical journal July 2004 issue

Solapur Medical Journal is free web journal published by medical
research council, Dr. V.M.Medical College, Solapur (India). This is
published quarterly & contains research articles, review articles &
interesting case reports.
Site adress is www.geocities.com/solapurmedicaljournal
visit & reply. Your discussion is welcome.
Dr. P.A.Gadgil,
Ass. editor, Solapur Medical Journal

No Comments

Microscopy Imaging Survey 2004

Hello

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the users. Therefore, you can help us to improve the usability of software!
For this reason, it would be very helpful if you could fill out the survey:

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(Usability Engineer)

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D-80689 Munich

Germany

Email: i…@ergosystems.de

Web: www.ergosystems.de (German)

No Comments

What is the medical cause of boxing knockouts?

With the subject of the summer olympics, boxing and wrestleing, and
the likd, it recently occurred to me.

In the general sport known of as ‘boxing’, the general idea is that
barring technical knockouts, a person is supposed to be pounded by
another person by various blows until one of the two people are
generally not able to stand.  They must, however, try to do this while
not trying to harm the legs in any way.

Then it occurred to me, what would cause someone to not be able to
stand after repeated blows, that could be as hard each opponent would
wish to administer, but would still have the shocks of the impacts
delivered evenly distributed by the boxing gloves?

Then I came up with these ideas:

1. Small strokes administered to the central or peripheral nervous
system.

2. Disassociation of the synapses of the central or peripheral nervous
system from the repeated impacts resulting in a coordinative amnesia.

3.The paralysis of various points of the nervous system from the
introduction of fluids from inflammation.

4. Shock from internal hemmoraging.

5. Psychological ‘fainting’, something similar to what women were
sometimes fabled to do in the 1800s.

If you remember, in boxing, no harm is supposed to happen to the legs,
and so it would seem that barring number 5, the only way of getting
someone to not be able to stand would be either at least temporary
paralysis or shock, since there are even rest periods between rounds
to at least somewhat remove the possible tiring of the legs.

What are the medical causes of ‘knockouts’ in boxing?

Comments (19)

Iron 'deficiency' protects from malaria

<<snip>>
 We conclude that iron deficiency was associated with protection from mild
clinical malaria
<<snip>>

 J Infect Dis. 2004 Aug 1;190(3):439-447. Epub 2004 Jul 02. Related Articles,
Links  

Iron Deficiency and Malaria among Children Living on the Coast of Kenya.

Nyakeriga AM, Troye-Blomberg M, Dorfman JR, Alexander ND, Back R, Kortok M,
Chemtai AK, Marsh K, Williams TN.

Kenya Medical Research Institute/Wellcome Trust Programme, Centre for
Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, and
Faculty of Health Sciences, Moi University, Eldoret, Kenya; Department of
Immunology, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
nyaker…@imun.su.se.

Both iron deficiency and malaria are common in much of sub-Saharan Africa, and
the interaction between these conditions is complex. To investigate the
association between nutritional iron status, immunoglobulins, and clinical
Plasmodium falciparum malaria, we determined the incidence of malaria in a
cohort of children between the ages of 8 months and 8 years who were living on
the Kenyan coast. Biochemical iron status and malaria-specific immune responses
were determined during 2 cross-sectional surveys. We found that the incidence
of clinical malaria was significantly lower among iron-deficient children
(incidence-rate ratio [IRR], 0.70; 95% confidence interval [CI], 0.51-0.99;
P<.05), that the incidence of malaria was significantly associated with plasma
ferritin concentration (IRR for log ferritin concentration, 1.48; 95% CI,
1.01-2.17; P<.05), and that iron status was strongly associated with a range of
malaria-specific immunoglobulins. We conclude that iron deficiency was
associated with protection from mild clinical malaria in our cohort of children
in coastal Kenya and discuss possible mechanisms for this protection.

PMID: 15243915 [PubMed - as supplied by publisher]

————————————————————————–
——

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

No Comments