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Protein S deficiency

Help! Our best friend was diagnosed to have Protein S deficiency. Does
anybody know more about this? Our friend is a male, mid-50′s, 3 wks.
post-CABG, was on Fen-phen for a year. Now, he has clotting problems
(bilateral DVT in LL) and the hematologist suspects he has heparin
allergy, a pre-leukemic syndrome (seen on a bm tap) with peripheral
WBC=30k, and Protein S deficiency. He also has anasarca and is going
downhill. Kidneys normal. He is currently on steroids and coumadin. Does
anybody have any suggestions as to diagnosis and management? Please
e-mail me or post a thread. Thank you.

Dr. Giselle
jus…@yours.com

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posted by admin in Uncategorized and have Comments (2)

2 Responses to “Protein S deficiency”

  1. admin says:

    - Hide quoted text — Show quoted text -

    On Fri, 28 Nov 1997 22:12:34 -0600, jus…@yours.com wrote:
    >Help! Our best friend was diagnosed to have Protein S deficiency. Does
    >anybody know more about this? Our friend is a male, mid-50′s, 3 wks.
    >post-CABG, was on Fen-phen for a year. Now, he has clotting problems
    >(bilateral DVT in LL) and the hematologist suspects he has heparin
    >allergy, a pre-leukemic syndrome (seen on a bm tap) with peripheral
    >WBC=30k, and Protein S deficiency. He also has anasarca and is going
    >downhill. Kidneys normal. He is currently on steroids and coumadin. Does
    >anybody have any suggestions as to diagnosis and management? Please
    >e-mail me or post a thread. Thank you.

    > I take Coumiden and Cardizem
    >Dr. Giselle
    >jus…@yours.com

    >——————-==== Posted via Deja News ====———————–
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  2. admin says:

    > Protein S is a part of the thrombolytic system, which serves to keep
    > clotting under control. It works in concert with protein S. Deficiency
    > of either protein C or S is congenital and unrelated to subsequent
    > development of leukemia, etc. Clinical manifestations are deep vein
    > thrombosis and/or pulmonary emboli after minimal trauma, adequate
    > anticoagulation, and usually at an early age. Treatment is life long
    > anticoagulation with coumadin, keeping the INR >2.5 It is critical to
    > start patients on heparin prior to coumadin (these factors were
    > discovered in researching the coumadin necrosis syndrome, a rare
    > disaster of skin infarction in patients started on coumadin without
    > heparin coverage).  There are several good reviews including recent
    > issues of Semin. in Hematology and the most recent Hematology texts.

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