Pathology and laboratory medicine

pathology, laboratory medicine, clinical pathology laboratories, pathology definition, clinical pathology, pathology laboratory, pathology report, human pathology, lab medicine

Sentinal Node Biopsy

I understand that in a sentinal node biopsy for melanoma, the sentinal
node is taken out, sectioned and examined for melanoma.  How is the
melanoma found in these sections?  Is it by appearance?  Is it by the
presence of melanin where it shouldnt be?  What specifically is the
sign of melanoma in these sections?

.
posted by admin in Uncategorized and have Comments (2)

2 Responses to “Sentinal Node Biopsy”

  1. admin says:

    dboh…@mindspring.com (Parallax) wrote in message <news:792abaf9.0409030909.9e0d255@posting.google.com>…
    > I understand that in a sentinal node biopsy for melanoma, the sentinal
    > node is taken out, sectioned and examined for melanoma.  How is the
    > melanoma found in these sections?  Is it by appearance?  Is it by the
    > presence of melanin where it shouldnt be?  What specifically is the
    > sign of melanoma in these sections?

    The slices are usually stained with a contrast agent and then
    ‘allegedly’ examined under a microscope for the presense of ‘nests’ of
    melanin cells.

  2. admin says:

    rudyguliani…@hotmail.com (rudy) wrote in message <news:861539f1.0409081803.6e86f985@posting.google.com>…
    > dboh…@mindspring.com (Parallax) wrote in message <news:792abaf9.0409030909.9e0d255@posting.google.com>…
    > > I understand that in a sentinal node biopsy for melanoma, the sentinal
    > > node is taken out, sectioned and examined for melanoma.  How is the
    > > melanoma found in these sections?  Is it by appearance?  Is it by the
    > > presence of melanin where it shouldnt be?  What specifically is the
    > > sign of melanoma in these sections?

    > The slices are usually stained with a contrast agent and then
    > ‘allegedly’ examined under a microscope for the presense of ‘nests’ of
    > melanin cells.

    Can you be a little more specific?  Does the contrast agent stain the
    melanin?
    I am interested because I have an idea for automation of the process
    where very small collections of cells could be seen.
    How thin are the slices?
    How many slices are viewed for one lymph node?

    Thanks for your help

    David OHara
    parallax Research, inc.