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spinal cord injury / iron

J Neurotrauma. 2003 Jun;20(6):583-591.  Related Articles, Links  

Quercetin Promotes Functional Recovery Following Acute Spinal Cord Injury.

Schultke E, Kendall E, Kamencic H, Ghong Z, Griebel RW, Juurlink BH.

Department of Anatomy and Cell Biology, and Department of Surgery, Division of
Neurosurgery, University of Saskatchewan, Saskatoon, Canada.

We tested the hypothesis that quercetin, a potent Fe(2+)-chelating flavonoid,
would decrease secondary damage following spinal cord trauma. MRI studies using
the relaxation of the T1 proton signal caused by Fe(2+) ions and the
dose-dependent reversal of this effect by addition of quercetin in aqueous
solution were used to guide us to the dosage of quercetin to be used in animal
experimentations. Forty-four male Wistar rats were used in two experimental
series to test the hypothesis that administration of quercetin improves
recovery of motor function after acute traumatic spinal cord injury. Animals
were subjected to laminectomy and subjected to an extradural 40-g force clip
compression for 5 sec at T7. Quercetin or saline was administered
intraperitoneally 1 h after injury and then every 12 hr thereafter. Recovery of
motor function was assessed using BBB scores at weekly intervals for 4 weeks. A
dose of 2.5 micromoles quercetin/kg body weight did not result in significantly
better functional outcome, whereas doses ranging from 5 to 100 micromoles
quercetin/kg body weight resulted in a significantly better functional outcome
with half or more of the animals walking, although with deficit; in contrast,
no animals walked in the group of saline-treated animals. No significant
differences in behavioral outcome were seen amongst the doses ranging from 5 to
100 micromol/kg, nor was there a difference if animals were treated for 4 or 10
days. Therapeutic outcome was coincident with more efficient iron clearance,
suggesting that one possible mechanism whereby quercetin decreases secondary
damage is through iron chelation.

PMID: 12906742 [PubMed - as supplied by publisher]

————————————————————————–
——

Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

.
posted by admin in Uncategorized and have Comments (5)

5 Responses to “spinal cord injury / iron”

  1. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20030811153345.22028.00000434@mb-m07.aol.com…

    - Hide quoted text — Show quoted text -

    > J Neurotrauma. 2003 Jun;20(6):583-591.  Related Articles, Links

    > Quercetin Promotes Functional Recovery Following Acute Spinal Cord Injury.

    > Schultke E, Kendall E, Kamencic H, Ghong Z, Griebel RW, Juurlink BH.

    > Department of Anatomy and Cell Biology, and Department of Surgery,
    Division of
    > Neurosurgery, University of Saskatchewan, Saskatoon, Canada.

    > We tested the hypothesis that quercetin, a potent Fe(2+)-chelating
    flavonoid,
    > would decrease secondary damage following spinal cord trauma. MRI studies
    using
    > the relaxation of the T1 proton signal caused by Fe(2+) ions and the
    > dose-dependent reversal of this effect by addition of quercetin in aqueous
    > solution were used to guide us to the dosage of quercetin to be used in
    animal
    > experimentations. Forty-four male Wistar rats were used in two
    experimental
    > series to test the hypothesis that administration of quercetin improves
    > recovery of motor function after acute traumatic spinal cord injury.
    Animals
    > were subjected to laminectomy and subjected to an extradural 40-g force
    clip
    > compression for 5 sec at T7. Quercetin or saline was administered
    > intraperitoneally 1 h after injury and then every 12 hr thereafter.
    Recovery of
    > motor function was assessed using BBB scores at weekly intervals for 4
    weeks. A
    > dose of 2.5 micromoles quercetin/kg body weight did not result in
    significantly
    > better functional outcome, whereas doses ranging from 5 to 100 micromoles
    > quercetin/kg body weight resulted in a significantly better functional
    outcome
    > with half or more of the animals walking, although with deficit; in
    contrast,
    > no animals walked in the group of saline-treated animals. No significant
    > differences in behavioral outcome were seen amongst the doses ranging from
    5 to
    > 100 micromol/kg, nor was there a difference if animals were treated for 4
    or 10
    > days. Therapeutic outcome was coincident with more efficient iron
    clearance,
    > suggesting that one possible mechanism whereby quercetin decreases
    secondary
    > damage is through iron chelation.

    > PMID: 12906742 [PubMed - as supplied by publisher]

    > ————————————————————————–
    > ——

    > Who loves ya.
    > Tom
    > Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    > Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    > DEAD PEOPLE WALKING

    http://pages.ivillage.com/ironjustice/deadpeoplewalking

    Good Grief, the ferrous fairy/ anti-ironist/ delusional internet psycho is
    back…..

    Who let him out of Bellevue??? Are they even aware he escaped???

    - Hide quoted text — Show quoted text -

  2. admin says:

    - Hide quoted text — Show quoted text -

    >Subject: Re: spinal cord injury / iron
    >From: "Dave King" LeFo…@verizonSpAm.net
    >Date: 8/12/2003 10:01 AM Mountain Daylight Time
    >Message-id: <eb8_a.6151$u%2….@nwrdny02.gnilink.net>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20030811153345.22028.00000434@mb-m07.aol.com…
    >> J Neurotrauma. 2003 Jun;20(6):583-591.  Related Articles, Links

    >> Quercetin Promotes Functional Recovery Following Acute Spinal Cord Injury.

    >> Schultke E, Kendall E, Kamencic H, Ghong Z, Griebel RW, Juurlink BH.

    >> Department of Anatomy and Cell Biology, and Department of Surgery,
    >Division of
    >> Neurosurgery, University of Saskatchewan, Saskatoon, Canada.

    >> We tested the hypothesis that quercetin, a potent Fe(2+)-chelating
    >flavonoid,
    >> would decrease secondary damage following spinal cord trauma. MRI studies
    >using
    >> the relaxation of the T1 proton signal caused by Fe(2+) ions and the
    >> dose-dependent reversal of this effect by addition of quercetin in aqueous
    >> solution were used to guide us to the dosage of quercetin to be used in
    >animal
    >> experimentations. Forty-four male Wistar rats were used in two
    >experimental
    >> series to test the hypothesis that administration of quercetin improves
    >> recovery of motor function after acute traumatic spinal cord injury.
    >Animals
    >> were subjected to laminectomy and subjected to an extradural 40-g force
    >clip
    >> compression for 5 sec at T7. Quercetin or saline was administered
    >> intraperitoneally 1 h after injury and then every 12 hr thereafter.
    >Recovery of
    >> motor function was assessed using BBB scores at weekly intervals for 4
    >weeks. A
    >> dose of 2.5 micromoles quercetin/kg body weight did not result in
    >significantly
    >> better functional outcome, whereas doses ranging from 5 to 100 micromoles
    >> quercetin/kg body weight resulted in a significantly better functional
    >outcome
    >> with half or more of the animals walking, although with deficit; in
    >contrast,
    >> no animals walked in the group of saline-treated animals. No significant
    >> differences in behavioral outcome were seen amongst the doses ranging from
    >5 to
    >> 100 micromol/kg, nor was there a difference if animals were treated for 4
    >or 10
    >> days. Therapeutic outcome was coincident with more efficient iron
    >clearance,
    >> suggesting that one possible mechanism whereby quercetin decreases
    >secondary
    >> damage is through iron chelation.

    >> PMID: 12906742 [PubMed - as supplied by publisher]

    >> ————————————————————————–
    >Good Grief, the ferrous fairy/ anti-ironist/ delusional internet psycho is
    >back…..

    >Who let him out of Bellevue??? Are they even aware he escaped???

    With a thread about ALS ..

    Notice you haven’t posted .. dick ..

    How’s that .. feel ..

    Who loves ya.
    Tom

    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  3. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20030811153345.22028.00000434@mb-m07.aol.com…

    Serious question Tom – where have you been for so long ?

    MB

  4. admin says:

    >Subject: Re: spinal cord injury / iron
    >From: "Manky Badger" m…@nospam.puritan.freeserve.co.uk
    >Date: 8/13/2003 2:11 PM Mountain Daylight Time
    >Message-id: <bhe62d$ab…@news6.svr.pol.co.uk>

    >"doe" <ironjust…@aol.comdoe> wrote in message
    >news:20030811153345.22028.00000434@mb-m07.aol.com…

    >Serious question Tom – where have you been for so long ?

    Making cows stagger and fall down ..

    Did it work .. ?

    Seems it did .. ;)

    Who loves ya.
    Tom
    Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
    Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
    DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking

  5. admin says:

    "doe" <ironjust…@aol.comdoe> wrote in message

    news:20030813164432.13267.00001388@mb-m10.aol.com…

    - Hide quoted text — Show quoted text -

    > >Subject: Re: spinal cord injury / iron
    > >From: "Manky Badger" m…@nospam.puritan.freeserve.co.uk
    > >Date: 8/13/2003 2:11 PM Mountain Daylight Time
    > >Message-id: <bhe62d$ab…@news6.svr.pol.co.uk>

    > >"doe" <ironjust…@aol.comdoe> wrote in message
    > >news:20030811153345.22028.00000434@mb-m07.aol.com…

    > >Serious question Tom – where have you been for so long ?

    > Making cows stagger and fall down ..

    > Did it work .. ?

    > Seems it did .. ;)

    Serious question Tom – were were you these last few months? – it’s been
    quiet here.