Pathology and laboratory medicine

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various vitreoretinal diseases / iron

Indian J Ophthalmol. 2004 Jun;52(2):145-8.  Related Articles, Links  

Trace elements iron, copper and zinc in vitreous of patients with various
vitreoretinal diseases.

Konerirajapuram NS, Coral K, Punitham R, Sharma T, Kasinathan N,
Sivaramakrishnan R.

Biochemistry Research Department, Sankara Nethralaya, Chennai, India.

PURPOSE: To measure the concentrations of iron, copper and zinc in human
vitreous and to interpret their levels with various vitreoretinal diseases like
proliferative diabetic retinopathy, retinal detachment, intraocular foreign
body, Eales’ disease and macular hole. METHODS: Undiluted vitreous fluid
collected during pars plana vitrectomy was used to measure trace elements using
an atomic absorption spectrophotometer. RESULTS: The level of vitreous iron
increased threefold in Eales’ disease (1.85 +/- 0.36 pg/ml), 2.5-fold in
proliferative diabetic retinopathy (1.534 +/- 0.17 pg/ml) and 2.3-fold in eyes
with intraocular foreign body (1.341 +/- 0.25 pg/ml) when compared with macular
hole (0.588 +/- 0.16 pg/ml). This was statistically significant (P < 0.05).
Zinc was found to be low in Eales’ disease (0.57 +/- 0.22 pg/ ml) when compared
with other groups, though the difference was not statistically significant.
CONCLUSION: The increased level of iron with decreased zinc content in Eales’
disease confirms the earlier reported oxidative stress mechanism for the
disease. In proliferative diabetic retinopathy and intraocular foreign body the
level of iron increases. This is undesirable as iron can augment glycoxidation,
which can lead to increased susceptibility to oxidative damage, in turn causing
vitreous liquefaction, posterior vitreous detachment and ultimately retinal
detachment and vision loss.

PMID: 15283220 [PubMed - in process]

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